This editorial marks the start of my three-year term as Editor-in-Chief (EiC) of the IEEE TRANSACTIONS ON AUDIO, SPEECH, AND LANGUAGE PROCESSING (T-ASL), right after the completion of my three-year term as EiC of the IEEE Signal Processing Magazine (SPM). To begin, I would like to thank Helen Meng for passing me a very strong T-ASL after three years of her outstanding work. I also thank Helen f...

Ticlopidine, an antiplatelet drug, undergoes extensive oxidative metabolism to form S-oxide, N-oxide, hydroxylated and dealkylated metabolites. However, metabolism of ticlopidine via conjugation has not been thoroughly investigated. In this study, multiple data acquisition and processing tools were applied to the detection and characterization of ticlopidine conjugates in rat bile. Accurate ful...

Real-time perception based on the simultaneous localization and mapping (SLAM) technology is of immense application potential in industry filed. In this work, we provide an extended Kalman filter (EKF) visual SLAM framework named Fusion VIO, which contains HDR imaging system, hardware synchronization, object detection, sensor fusion, semantic fusion. Notably, VIO well fuses loop closure informa...

Translocation, a coordinated movement of two tRNAs together with mRNA on the ribosome, is catalyzed by elongation factor G (EF-G). The reaction is accompanied by conformational rearrangements of the ribosome that are, as yet, not well characterized. Here, we analyze those rearrangements by restricting the conformational flexibility of the ribosome by antibiotics binding to specific sites of the...