Abstract Objective: Informant ratings of adaptive functioning are a valuable source information that can support diagnosis and treatment planning monitor change. The Adaptive Behavior Assessment System (ABAS-II) Vineland Scales (VABS-II) well-known questionnaires used in clinical practice. This study assessed the correspondence between ABAS-II VABS-II composite scales adults with Down Syndrome ...

OBJECTIVE We examined whether metabolic conditions (MCs) during pregnancy (diabetes, hypertension, and obesity) are associated with autism spectrum disorder (ASD), developmental delays (DD), or impairments in specific domains of development in the offspring. METHODS Children aged 2 to 5 years (517 ASD, 172 DD, and 315 controls) were enrolled in the CHARGE (Childhood Autism Risks from Genetics...

One of the consequences of genetic impairments in early childhood is their long-term effect on children's developmental skills in communication, learning, and adaptive behaviors. Functional assessment provides families and clinicians with a common language for describing a child's strengths and limitations in self-care (feeding, dressing, grooming, bathing, continence), mobility, and communicat...

Deficits in social behavior in mice lacking the CD38 gene have been attributed to impaired secretion of oxytocin. In humans, similar deficits in social behavior are associated with autistic spectrum disorder (ASD), for which genetic variants of CD38 have been pinpointed as provisional risk factors. We sought to explore, in an in vitro model, the feasibility of the theory that restoring the leve...

BACKGROUND Internalizing problems, anxiety, depression, withdrawal, and consequent social problems are frequently observed in children with brain tumors. The objective of this work is to describe the relationship between these psychological problems and the type of parent-child communication established about the disease. PROCEDURES A group of 64 children surviving a brain tumor (aged 4-18 ye...

Intellectual disability (ID) is often accompanied by more significant delays in emotional development than cognitive development. Diagnostic assessment can provide insight into functioning. However, few standardized instruments are available. Examine the reliability and validity of Scale Emotional Development–Short (SED-S) children with ID. This methodological instrument validation study was co...

Impaired motor coordination is prevalent in children with Autism Spectrum Disorders (ASD) and affects adaptive skills. Little is known about the development of motor patterns in young children with ASD between 2 and 6 years of age. The purpose of the current study was threefold: (1) to describe developmental correlates of motor coordination in children with ASD, (2) to identify the extent to wh...