Bharngi is one of the drugs of Ayurvedic meteria medica which is mainly indicated in the respiratory disorders. One the botanical sources of Bharngi is Clerodendrum serratum Linn. another species Pygmaeopremna herbacea is being in use for Bharngi. Clerodendrum serratum Linn. (Family: Verbenaceae) is very widely distributed in tropical and subtropical regions of the world. In Ayurveda it is used...

PURPOSE Vinorelbine (Navelbine) is an orally absorbable Vinca with broad antitumor activity. It differs from other Vinca in that it is structurally modified on the catharanthine nucleus and has differential actions on tubulin that render it less neurotoxic than other compounds in this class. We conducted a phase I study of vinorelbine given the activity of Vinca alkaloids in many pediatric tumo...

Aberrant expression of beta-tubulin isotypes is frequently described in tumor tissues and tubulin-binding agent (TBA)-resistant cell lines. There is limited understanding of the role of specific beta-tubulin isotypes in cellular sensitivity to TBAs, and to gain insights into the functional role of betaII- and betaIVb-tubulin, we examined these isotypes in lung cancer cell lines NCI-H460 (H460) ...

Prediction of Physico-Chemical Properties for REACH Based on QSPR Models Guillaume Fayet, Patricia Rotureau, Vinca Prana, Carlo Adamo INERIS, Parc Technologique Alata, BP2, 60550 Verneuil-en-Halatte, France Laboratoire d’Electrochimie, Chimie des Interfaces et Modélisation pour l’Energie, CNRS UMR-7575, Chimie ParisTech, 11 rue P. et M. Curie, 75231 Paris, France Institut Universitaire de Franc...

Blocking cell division through the inhibition of mitosis is one of the most successful clinical strategies for the treatment of cancer. Taxanes and vinca alkaloids are in widespread use and have demonstrated substantive therapeutic efficacy. Both classes of compounds bind directly to tubulin, a structural component of the mitotic spindle. The ubiquitous utilization of tubulin in cell division i...