D espite many years of investigation, the pathophysiology of vasospastic attacks in primary (idiopathic) Raynaud's disease is unknown. In secondary Raynaud's phenomenon, it is understandable that digital arteries may close during normal sympathetic stimuli or external pressure on the fingers due to low blood pressure distal to stenoses or obstructions or thickened vessel walls or to decreased b...

The present post-mortem study of a brain from an Alzheimer patient showed on a T(2)∗-weighted gradient-echo 7.0-T MRI of a coronal brain section a hyposignal in the hippocampus, suggesting a microbleed. On the corresponding histological examination, only iron deposits around the granular cellular layer and in blood vessel walls of the hippocampus were observed without evidence of a bleeding. Th...

Bleeding diathesis is a recognised complication of amyloid disease. Localised and generalised bleeding manifestations are usually associated with intravascular coagulopathy related to isolated or multiple coagulation factor deficiencies. Recently, there have been reports of haemorrhage due to amyloid deposition in blood vessel walls and in the perivascular region leading to increased fragility ...

Fig. 1. Three-dimensional orthogonal multi-planar reconstruction images of postmortem porcine pneumo-myocardium. In 1984, Lunkenheimer et al. reported a trans-coronary pneumo-myocardium technique to visualize myocardial architecture in Investigative Radiology. Pneumo-myocardium was produced with continuous transcoronary air injection at 600 mmHg. Capillary vessel walls were dissected and myocar...

Abifract: Ef}ccts of Freezing on Major Arteries • Thirty experiments were performed in dogs to assess the effects of freezing on carotid and femoral arteries. These vessels withstood freezing and thawing without rupture. Blood within the vessels did not clot and was lysed during thawing. Histological changes of vessel walls consisted of early degeneration followed by a reparative process. Occas...

We report a rare case of dry eyes and dry mouth caused by primary amyloidosis. A 66-year-old woman with keratoconjunctivitis sicca and xerostomia died of acute respiratory failure. Shirmer's test, gum test, and sialography indicated Sjögren's syndrome. Lip biopsy revealed amyloid deposition around the salivary ducts. Bence-Jones protein was noted in the urine. At autopsy, amyloid deposition was...

Myocardial ischemia is transmurally heterogeneous where the subendocardium is at higher risk. Stenosis induces reduced perfusion pressure, blood flow redistribution away from the subendocardium, and consequent subendocardial vulnerability. We propose that the flow redistribution stems from the higher compliance of the subendocardial vasculature. This new paradigm was tested using network flow s...