1 Bacteriology Group, International Centre for Genetic Engineering & Biotechnology, Trieste, Italy 9 and 2 Plant Bacteriology Group, International Centre for Genetic Engineering & Biotechnology, 10 Biosafety Outstation, Ca’Tron, Treviso, Italy 11 12 13 14 Running title: Inter-kingdom signaling in Xanthomonas oryzae 15 16 17 18 Corresponding author: Vittorio Venturi, Bacteriology Group, Internat...

TCR engagement leads to the up-regulation of genetic programs that can both activate and inhibit T cell function. The early growth receptor (Egr) proteins Egr-2 and Egr-3 have recently been identified as TCR-induced negative regulators of T cell function. NAB2 (NGFI-A-binding protein 2) is both a coactivator and a corepressor of Egr-mediated transcription and has been implicated in regulating S...

This study explored the effects of propofol on c-Fos and Egr-1 in neuroblastoma (N2A) cells. We demonstrate that propofol induced the expression of c-Fos and Egr-1 within 30 and 60 min of exposure time. At 16.8 microM concentration, propofol induced a 6 and 2.5-fold expression of c-Fos and Egr-1, respectively. However, at concentrations above 100 microM, propofol failed to induce expression of ...

Hypoxic induction of the early growth response-1 (Egr-1) transcription factor initiates proinflammatory and procoagulant gene expression. Orthotopic/isogeneic rat lung transplantation triggers Egr-1 expression and nuclear DNA binding activity corresponding to Egr-1, which leads to increased expression of downstream target genes such as interleukin-1β, tissue factor, and plasminogen activator in...

The zinc finger transcription factor Egr-1 is critical for coupling extracellular signals to changes in cellular gene expression. In the hippocampus and amygdala, two major central regions for memory formation and storage, Egr-1 is up-regulated by long-term potentiation (LTP) and learning paradigms. Using Egr-1 knockout mice, we showed that Egr-1 was selectively required for late auditory fear ...

Early growth response-1 (Egr-1) is involved in the regulation of cell growth. Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells. Suppression of PMA-induced Egr-1 was dependent on the expression level of PLD isozymes. Overexpression of catalytically inactive PL...

Due to the increasing sales of extended-range hybrid vehicles and increasingly stringent emission regulations for light in China, performance diesel engines range extenders plateau region have attracted attention. In order obtain superior operating at high altitudes, a multi-objective optimization optimal economic point engine was performed an altitude 1960 m. A system model with MC-EGR-VNT (ME...

The purpose of this paper is to find the optimal geometry of Venturi for the production of biodiesel by hydrodynamic cavitation. Intensive methods such as hydrodynamic cavitation eliminate the limitation of mass transfer in the transesterification reaction. In this paper, a venturi design was developed to create cavitation in biodiesel production. The most important property of ven...

One essential part of automated diagnosis systems for SI engines is due to elements of air path system. The diagnosis task is getting more challenging by including Exhaust Gas Recirculation (EGR) which its transient effects on temperament complexity of the air-path system are quite significant. The faults occur in this subsystem can result in deviation in air-fuel ratio, which causes increased ...

Endothelial cells (ECs) subjected to shear stress constantly release nitric oxide (NO). The effect of NO on shear stress-induced endothelial responses was examined. ECs subjected to shear stress induced a transient and shear force-dependent increase in early growth response-1 (Egr-1) mRNA levels. Treatment of ECs with an NO donor, S-nitroso-N-acetylpenicillamine (SNAP) or 3-morpholinosydnonimin...