Atrial fibrillation is associated with increased expression of ventricular myosin isoforms in atrial myocardium, regarded as part of a dedifferentiation process. Whether reexpression of ventricular isoforms in atrial fibrillation is restricted to transcripts encoding for contractile proteins is unknown. Therefore, this study compares atrial mRNA expression in patients with permanent atrial fibr...

Ventricular fibrillation refractory to cardiopulmonary resuscitation including multiple transthoracic defibrillations occurred in four patients during 1,215 consecutive ventricular tachycardia induction studies. A technique of emergency intracardiac defibrillation for management of refractory ventricular fibrillation is described. In four patients, stable monomorphic ventricular tachycardia (32...

A promising therapy for ventricular fibrillation--a life-threatening cardiac arrhythmia--is implantation of an automatic defibrillator. A critical component of such a device is the system that detects the presence of ventricular fibrillation. Automatic systems for detecting ventricular fibrillation have been tested with arrhythmias produced by electric shocks in normal canine hearts, but have n...

In this part of a series on founder mutations in the Netherlands, we review familial idiopathic ventricular fibrillation linked to the DPP6 gene. Familial idiopathic ventricular fibrillation determines an intriguing subset of the inheritable arrhythmia syndromes as there is no recognisable phenotype during cardiological investigation other than ventricular arrhythmias highly associated with sud...

Nine hundred and sixty-nine coronary care patients with acute myocardial infarction were followed for one year. Atrial fibrillation was documented in 107 patients. Compared with patients without atrial fibrillation, those with this arrhythmia were older, had clinically more severe infarction, and had a higher frequency of ventricular fibrillation or tachycardia, and right bundle-branch block. T...

introduction: amiodarone is an effective drug for life-threatening arrhythmias like recurrent ventricular fibrillation and atrial fibrillation. amiodarone creates rarely genitourinary side effects are seen. these are epididymitis, testicular dysfunction and impotance. amiodarone aggregates and triggers inflammation in the head of the epididym. case report: we present the case of a patient who d...

background: left ventricular dysfunction is one of the most powerful predictors of early and late outcomes in patients who undergo coronary artery bypass grafting (cabg). the aim of this study was to assess the early results of cabg that predict 30-day mortality and prolonged length of hospital stay (los) after cabg in patients with an ejection fraction (ef) of 30% or less. methods: seven hundr...

Coronary aiteriovenous electrolyte differences were studied in normoand hypercnpneic dogs at normal temperature and at 24 C. The ions measured were sodium, potassium, calcium, magnesium, ohlorideand hydrogen. Coronary arteriovenouselectrolytedifferencesdid not changeduringcooling in 16 dogs which did not suffer ventricular fibrillation. Ten hypercapneic hypothermic dogs exhibited characteristic...

V ENTRICULAR fibrillation is the most serious of all arrhythmias. It was first described in 1849 by Ludwig and Hoffa.92 Its presence even for a short interval is usually incompatible with life. With the onset of ventricular fibrillation there is an immediate cessation of circulation with a series of rapid irregular undulations that replace the coordinated contractions of the ventricle. These os...

Irregular heartbeats and different forms of ventricular ectopic activity are a common occurrence among elite athletes with high contractile cardiac capacity. At the same time, experiments demonstrated that the electrical stimulation threshold, causing ventricular fibrillation, increases during adaptation to physical exercise, without the increase in the contractile cardiac capacity. The researc...