OBJECTIVES To ascertain the immediate outcome of preterm infants with respiratory distress syndrome (RDS) on Bubble CPAP and identify risk factors associated with its failure. STUDY DESIGN Prospective analytical study. SUBJECTS Inborn preterm infants (gestation 28 to 34 weeks) admitted to the NICU with respiratory distress and chest X ray suggestive of RDS. INTERVENTION Bubble CPAP with b...

Centrosome cohesion and segregation are accurately regulated to prevent an aberrant separation of duplicated centrosomes and to ensure the correct formation of bipolar spindles by a tight coupling with cell cycle machinery. CPAP is a centrosome protein with five coiled-coil domains and plays an important role in the control of brain size in autosomal recessive primary microcephaly. Previous stu...

Background: Obstructive sleep apnoea (OSA) is a common and potentially reversible cause of systemic hypertension. The mechanisms whereby OSA leads to hypertension and the effects of treatment on arterial function, however, are not well established. Microvascular arterial endothelial and smooth muscle function was assessed in subjects with OSA before and after treatment with continuous positive ...

OBJECTIVES/HYPOTHESIS Nasal continuous positive airway pressure (CPAP) is the standard therapy for sleep apnea; however, compliance rates are historically poor. Among the most commonly cited reasons for nonadherence is nasal obstruction. Our study sought to examine if nasal surgery actually increases CPAP compliance. STUDY DESIGN Prospective case series. METHODS Nasal CPAP-intolerant obstru...

Background: The simplest method of initiating and maintaining therapeutic continuous positive airways pressure (CPAP) therapy for obstructive sleep apnoea (OSA) has not been established. Methods: Ninety eight subjects with OSA requiring CPAP treatment (more than 10 dips in oxygen desaturation of .4% per hour of sleep study and Epworth Sleepiness Score (ESS) .9) were randomised prospectively to ...

The clinical guidelines for the evaluation, management, and longterm care of obstructive sleep apnea (OSA) in adults emphasize a multidisciplinary, chronic care approach to the treatment and management of OSA [1]. The guidelines, consistent with earlier practice parameters [2], include consensus standards to monitor early continuous positive airway pressure (CPAP) compliance (ie, adherence) for...

BACKGROUND To determine whether the prehospital use of continuous positive airway pressure (CPAP) therapy is associated with a reduced rate of endotracheal intubation in patients with an acute respiratory disorder brought to the emergency department (ED). METHODS We reviewed medical records of patients with acute respiratory distress who had been treated with CPAP in the Mobile Intensive Care...

OBJECTIVES To study the effects of augmentation of continuous positive airway pressure (CPAP) education and support on compliance and outcome in patients with obstructive sleep apnea (OSA). DESIGN A randomized, controlled, parallel study of basic vs augmented CPAP education and support. SETTING A university teaching hospital. PATIENTS A total of 108 OSA patients randomized into basic-supp...

OBJECTIVE To assess continuous positive airway pressure (CPAP) compliance and factors associated with CPAP compliance among Chinese patients with obstructive sleep apnea (OSA). DESIGN A prospective study of 112 consecutive patients with newly diagnosed OSA commencing CPAP treatment. SETTING A university teaching hospital. MEASUREMENTS AND RESULTS The following factors were evaluated for a...

STUDY OBJECTIVES Mouth leak compromises nasal continuous positive airway pressure (CPAP) therapy. We hypothesized that patients who breathe mainly through their mouths during sleep, compared to those who breathe mainly through their noses, would have more mouth leak during CPAP and therefore lower adherence to CPAP. DESIGN A case-control study to compare adherence to CPAP at 1 year in mouth b...