.........................................................................................................................................................8 INTRODUCTION............................................................................................................................................10 REVIEW OF THE LITERATURE .................................................................

Purpose: Venlafaxine hydrochloride sustained release formulation increases patient compliance by reducing frequency of administration and it also reduces side effects like nausea and vomiting. Hence the objective of present investigation was to develop triple layer sustained release tablets of venlafaxine HCl using xanthan gum or polyethylene oxide. Methods: The venlafaxine HCl 150 mg sustained...

OBJECTIVE To assess whether use of the antidepressant venlafaxine is associated with an increased risk of sudden cardiac death or near death compared with other commonly used antidepressants. DESIGN Population based observational study. SETTING We did a nested case-control analysis within a new user cohort formed using the United Kingdom General Practice Research Database. PARTICIPANTS Ne...

Atracurium is a nondepolarizing skeletal muscle relaxant used to facilitate endotracheal intubation and to induce skeletal muscle relaxation during surgery or mechanical ventilation. The drug undergoes a spontaneous non-enzymatic biotransformation, yielding laudanosine and an acrylate moiety. This report documents the case of a 45-year-old anesthesiologist who was found dead at the hospital whe...

To the Editor: We recently observed three occurrences of false-positive results for phencyclidine (PCP) on urine samples tested with the Syva RapidTest d.a.u. 9 Test Panel (Syva Company, subsidiary of Dade Behring Inc.). The RapidTest d.a.u. 9 device is a singleuse, one-step, solid-phase immunochromatographic assay for the qualitative, discrete detection of several drugs/drug metabolites in hum...

BACKGROUND Patterns of healthcare utilization and costs in patients beginning pharmacotherapy for generalized anxiety disorder (GAD) have not been well characterized. METHODS Using a large US health insurance database, we identified all patients with evidence of GAD (ICD-9-CM diagnosis code 300.02) who initiated pharmacotherapy with medications commonly used to treat GAD (eg, selective seroto...

Correspondence: Lucilla Mansuy Pierre Fabre Médicament, 31319 Labège Cedex, France Tel +33 014 910 8117 Fax +33 014 910 9626 email [email protected] Abstract: Specific serotonin norepinephrine reuptake inhibitors (SNRIs) have been described as “better tolerated tricyclic antidepressants” or as “boosted” selective serotonin reuptake inhibitors (SSRIs). Venlafaxine has become a ther...

The emergence of depression in the course of schizophrenia is common and arouses much interest and therapeutic concern. It has been associated with a less favorable prognosis and increased incidence of suicide. However, relatively few treatment studies have been performed in this area. The use of a combination of antidepressants and antipsychotic agents is controversial. We report an open-label...

OBJECTIVE To estimate the cost effectiveness of different classes of antidepressants in the UK National Health Service. DESIGN, PATIENTS AND INTERVENTIONS: The use of the serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine) reuptake inhibitor (SNRI) venlafaxine was compared with that of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) in p...