The Vehicle Routing Problem with Stochastic Demands (VRPSD) is a variation of the classical Capacitated Vehicle Routing Problem (CVRP) in which the demand of each customer is modeled as a random variable and its realization is only known upon vehicle arrival to the customer site. Under this uncertain scenario, a possible outcome is that the demand of a customer ends up exceeding the remaining c...

PURPOSE Intravitreal recombinant tissue plasminogen activator (rtPA) is used off-label for the surgical management of submacular hemorrhage, a severe complication of neovascular age-related macular degeneration. rtPA is approved for coronary and cerebral thrombolysis. However, in ischemic stroke rtPA is known to increase excitotoxic neural cell death by interacting with the N-methyl-D-aspartate...

Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical anti-inflammatory corticosteroid in preventing O3-induced rhinitis and mucous cell metaplasia in rat nasal epithelium. Male F344 rats were exposed to...

This study aims to investigate the renoprotective effect of recombinant human erythropoietin (rhEPO) treatment could preserve tubular epithelial cell regeneration and ameliorate renal fibrosis by dual inhibition of stress-induced senescence and EMT in unilateral ureteric obstruction (UUO) mouse model. UUO or sham-operated mice were randomly assigned to receive rhEPO or vehicle treatment and wer...

Recent studies suggest that thromboxane (TX) mediates a significant component of angiotensin II (ANG II)-induced hypertension. However, there is little information to support the hypothesis that this relationship is important during chronic, physiological increases in ANG II, particularly while controlling for variation in endogenous ANG II levels induced by TX inhibition. This study tested tha...

in this paper an optimal controller is proposed for a self-balancing electrical vehicle called segway pt. this vehicle has one platform and two wheels on the sides and the rider stands on the platform. a handlebar, as a navigator, is attached to the body of segway, with which the rider controls the vehicle. since segway uses electrical energy produced by batteries, resource consumption manageme...

in our country, student transportations’ security and driving accidents statistics for students is one of the major concerns for relevant organizations such as educational organization. in current year, a system, was named sepand, was formed in city taxi driver :::::::union::::::: by educational organization, naja traffic and city taxi driver :::::::union:::::::. in this systems’ plan, basis on...

Vehicle Routing Problem (VRP) is addressed to a class of problems for determining a set of vehicle routes, in which each vehicle departs from a given depot, serves a given set of customers, and returns back to the same depot. On the other hand, simultaneous delivery and pickup problems have drawn much attention in the past few years due to its high usage in real world cases. This study, therefo...

The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds cannot discriminate whether the decrease of venous oxygen saturation is dependent of cranial vasoconstrictor. In the present study, vehicle (n = 10), do...