hemangiopericytoma is a rare vascular tumor observed mostly in adults. it usually presents with a painless slowly enlarging mass. the infantile type with much rarer occurrence has a different course compared to adults. very few case reports have been described in the literature with disease onset in the infancy. the first reported case of infantile hemangiopericytoma of limbs from the middle ea...

Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...

Hemangiopericytoma is a rare vascular tumor observed mostly in adults. It usually presents with a painless slowly enlarging mass. The infantile type with much rarer occurrence has a different course compared to adults. Very few case reports have been described in the literature with disease onset in the infancy. The first reported case of infantile hemangiopericytoma of limbs from the Middle ...

Haemangioendothelioma is a rare tumor that is both clinically and histologically intermediate between angiosarcoma and haemangioma. It is usually a solitary, slow-growing nodule on distal areas or extremities. The onset is frequently before 25 years of age with a male preponderance. Histologically, two components are important: dilated vascular channels and spindle cells elements with som...

PURPOSE New strategies to detect tumor angiogenesis and monitor response of tumor vasculature to therapy are needed. Contrast ultrasound imaging using microbubbles targeted to tumor endothelium offers a noninvasive method for monitoring and quantifying vascular effects of antitumor therapy. We investigated the use of targeted microbubbles to follow vascular response of therapy in a mouse model ...

Brain tumor-associated cerebral edema arises because tumor capillaries lack normal blood-brain barrier function; vascular permeability factor (VPF, also known as vascular endothelial growth factor, VEGF) is a likely mediator of this phenomenon. Clinically, dexamethasone reduces brain tumor-associated vascular permeability through poorly understood mechanisms. Our goals were to determine if supp...

The generation of vascular stroma is essential for solid tumor growth and involves stimulatory and inhibiting factors as well as stromal components that regulate functions such as cellular adhesion, migration, and gene expression. In an effort to obtain a more integrated understanding of vascular stroma formation in breast carcinoma, we examined expression of the angiogenic factor vascular perm...

1. Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, et al. Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies. Pediatrics 2015;136:e203‐14. 2. Hanson J, Gorman J, Reese J, Frazier G. Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1. Front Biosci 2007;12:2279‐90. 3. ...

Tumor vessel co-option is a crucial predictor for tumor invasiveness but easy to ignore in vascular targeting therapy. A high density of located alongside the frontier predicted tendency invasion and regional metastasis. Herein, novel second near-infrared (NIR-II) nanoagent (Coi8DFIC-sorafenib nanoparticles, CS NPs [CS NPs]) was constructed with an organic Coi8DFIC dye sorafenib, which demonstr...