We present a calculus which can transfer specifications to objects for the development of real-time systems. The object model is based on a practical OO development technique—HRT-HOOD. A real-time logic is specified by extending a sound formal method for real-time systems— TAM, to formalise the object model. With integration of HRT-HOOD and TAM, the advantages of object-oriented structured meth...

This paper reports on a survey of Singapore companies’ intention to adopt negotiation support systems (NSS). Data collected were tested based on two theoretical models, the theory of planned behavior (TPB) and the technology acceptance model (TAM). Preliminary findings showed that TPB provides a better prediction of intention to adopt NSS than TAM does, with subjective norm and perceived behavi...

The use of dietary isoflavone supplements by postmenopausal women with breast cancer is increasing. We investigated interactions between the soy isoflavone, genistein, and an antiestrogen, tamoxifen (TAM), on the growth of estrogen (E)-dependent breast cancer (MCF-7) cells implanted in ovariectomized athymic mice. We hypothesized that weakly estrogenic genistein negate/overwhelm the inhibitory ...

This study was designed to investigate the role of protein kinase C (PKC) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in tamoxifen (TAM)-induced apoptosis and drug resistance in human breast cancer cells. Drug-sensitive, or estrogen receptor (ER)-positive human breast carcinoma cells (MCF-7) and the multi-drug-resistant variant (ER-negative) MCF-7/ADR cells were treated wit...

We have demonstrated previously that cisplatin (DDP) and tamoxifen (TAM) act synergistically to kill human melanoma T-289 cells, and that the observed synergy is lost in the 3-fold TAM-resistant subline, 289/TAM6. We have identified the intracellular antiestrogen-binding sites (AEBSs), defined by their ability to bind antiestrogens while having no affinity for estrogen, as a possible mediator o...

This paper proposes a configurable TAM-Bus, a P1500 compliant Test Access Mechanism (TAM), and the TAMBus controller (TAM-controller) that is interfaced with JTAG at chip level of chip. All IP (Intellectual Property) cores’ test can be controlled through the TAP under the control of the TAM-controller. The test architecture we presented has been implemented in an industry SoC. The test coverage...

The effects of the antiestrogen tamoxifen (TAM) on the growth of two hormone-sensitive human tumors have been examined in athymic mice. The endometrial tumor, EnCalOl, was stimulated to grow by TAM either alone or when combined with estradiol. This contrasted with the nonstimulation of the breast tumor, MCF-7, by TAM alone and the antago nist action of TAM on estradiol-stimulated growth of MCF-...

The existing literature on Bantu verbal semantics demonstrated that inherent semantic content of verbs pairs directly with the selection of tense, aspect and modality formatives in Bantu languages like Chasu, Lucazi, Lusamia, and Shiyeyi. Thus, the gist of this paper is the articulation of semantic classification of verbs in Kiswahili based on the selection of TAM types. This is because the sem...

The antiestrogen tamoxifen (TAM) is extensively metabolized by cytochrome P-450 in humans and rodents. The active, estrogen receptor-binding metabolites, 4-hydroxy TAM (OHT) and N-desmethyl TAM (DMT) have been well characterized. We showed that the s.c. injection of 1 mg/kg TAM in adult female Sprague Dawley rats bearing carcinogen-induced mammary tumors resulted in rapid serum decline of paren...

Targeted inhibition of members of the TAM (TYRO-3, AXL, MERTK) family of receptor tyrosine kinases has recently been investigated as a novel strategy for treatment of hematologic malignancies. The physiologic functions of the TAM receptors in innate immune control, natural killer (NK) cell differentiation, efferocytosis, clearance of apoptotic debris, and hemostasis have previously been describ...