Hypercoagulability increases risk of thrombi that cause cardiovascular events. Here we identify plasma sodium concentration as a factor that modulates blood coagulability by affecting the production of von Willebrand factor (vWF), a key initiator of the clotting cascade. We find that elevation of salt over a range from the lower end of what is normal in blood to the level of severe hypernatremi...

New NTT/SOFI near-IR narrow-band imaging and spectroscopy reveals an additional four Wolf-Rayet (WR) stars in the massive cluster Westerlund 1, bringing the total WR population to 24. Sixteen of the WR stars in Wd1 have been classified WN5–11, while eight are WC8–9. An observed WR to RSG/YHG ratio of ∼3 suggests an age of 4.5–5.0 Myr, with WR stars descended from 40–55M⊙ progenitors. On the bas...

In this paper, we examine factors associated with poor pregnancy outcomes among teenagers in South Nyanza region of Kenya. The analysis is based on a recent WHO funded study on Adolescent safe motherhood in the region, which involved a survey of 1247 adolescents aged 12-19 and in-depth interviews with 39 of the adolescents who had experienced very early pregnancies or a pregnancy wastage. The i...

Wolf-Rayet (WR) stars are the chemically evolved descendents of O stars, such that they trace massive star formation. Here we present results of recent VLT/FORS surveys of WR stars in near by spiral and irregular galaxies and consider individual WR stars as progenitors of Type Ib/c core-collapse supernovae. Young massive clusters hosting large WR populations may be used as templates for high-re...

OBJECTIVE We examined the relationship among the serum omega-3 and omega-6 fatty acid (O3FA and O6FA) levels, serum C-reactive protein (CRP) levels, and arterial stiffness/wave reflection (AS/WR) in healthy Japanese men. METHODS In 2206 Japanese healthy men, parameters related to the AS/WR (i.e., brachial-ankle pulse wave velocity and radial arterial pulse wave analysis) were measured. RESU...

A liquid chromatographic method using electrochemical detection is presented for measuring the thiol WR-1065 12-(3-aminopropylamino) ethanethiol] and its symmetrical disulfide WR-33278 [NH2(CH2)3NHCH2CH2S]2. WR- 1065 is the active, radioprotective drug derived from the phosphorothioate pro-drug WR-2721 (amifostine). External standard curves for both compounds were linear over the range of 40-20...