Animal models of autoimmunity to the retina mimic specific features of human uveitis, but no model by itself reproduces the full spectrum of human disease. We compared three mouse models of uveitis that target the interphotoreceptor retinoid binding protein (IRBP): (i) the "classical" model of experimental autoimmune uveitis (EAU) induced by immunization with IRBP; (ii) spontaneous uveitis in I...

OBJECTIVE To evaluate CD4(+)Foxp3(+) (forkhead box P3) T-regulatory cell populations in patients with uveitis and to determine if T-regulatory cell populations are associated with disease features. METHODS Patients with uveitis were evaluated for CD4(+)Foxp3(+) T-regulatory cells by flow cytometry. Systemic and ocular diagnoses, disease activity, and the presence of cystoid macular edema were...

OBJECTIVES The aim of the present study is to investigate the demographics, aetiologies, complications, treatments and visual outcomes in paediatric uveitis patients in the French-speaking part of Switzerland. METHODS Chart review of all patients diagnosed with uveitis before the age of 16 years, presenting to two tertiary referral centres (uveitis and paediatric rheumatology clinics) in Laus...

AMA Łazicka-Gałecka M, Guszkowska Gałecki T, Dziedziak J, Kamińska A, Szaflik J. Epidemiology, pathophysiology and diagnosis of uveitic glaucoma ocular hypertension secondary to uveitis. Klinika Oczna / Acta Ophthalmologica Polonica. 2023;125(1):7-12. doi:10.5114/ko.2023.126355. APA Łazicka-Gałecka, M., Guszkowska, Gałecki, T., Dziedziak, J., Kamińska, A., & Szaflik, (2023). Polonica, 125(1), 7...

PURPOSE To understand the pathogenic mechanism of leptospiral uveitis by determining the profile of infiltrating cells, the levels of cytokines, and the causative factor in aqueous humor (AH). METHODS AH and blood samples were collected from 22 patients with leptospiral uveitis that was confirmed by microscopic agglutination test (MAT). Nine patients with Behçet's uveitis, 10 with phacolytic ...

results this cross-sectional study included 92 patients (47 male and 45 female) with mean age of 32.1 ± 13.16 years (ranging from nine to 61 years of age). mean duration of vitiligo was 10.84 ± 10.17 years. the most common distribution of the lesions was on the upper limbs (60.8%) and the least was on the genital region (10.8%). positive family history was found in 26 (28.3%) patients. diabetes...

First results of the uveitis outcome study of the multinational interdisciplinary working group for uveitis in childhood (MIWGUC) Ivan Foeldvari, Gabriele Brumm, C Delibero, Kerstin Gerhold, Valeria Maria Gerloni, Kaisu Kotaniemi, Kirsten Minden, Eilsabeth Miserochchi, Uwe Pleyer, Gabriele Simonini, Susan Nielsen, I Sandfeldt, Martina Niewerth, Sandra Schenck, Arnd Heiligenhaus, The Multination...

PReS-FINAL-2063: Proposed criteria for activity, damage and impact of juvenile idiopathic arthritis associated uveitis: consensus effort from the multinational interdisciplinary working group for uveitis in childhood (MIWGUC) I Foeldvari, A Heiligenhaus, J Anton, R Ramanan, C Edelsten, T Saurenmann, B Bodaghi, K Kotaniemi, S Nielsen, E Rabinovich, Multinational Interdisciplinary Working Group f...

AIM To investigate peripheral blood lymphocyte phenotype in patients with intermediate uveitis using CD69, chemokine receptor, and cytokine expression. METHODS Peripheral blood lymphocytes of 18 patients with idiopathic intermediate uveitis and 6 patients with presumed sarcoid intermediate uveitis were evaluated for CD4(+) T cell expression of CD69, CCR4, CCR5, CXCR3 and the intracellular cyt...

BACKGROUND The aim of this study is to report two interesting cases of cytomegalovirus (CMV) anterior uveitis following topical prostaglandin analogue administration for glaucoma. Two retrospective case studies are presented. FINDINGS A 40-year-old immunocompetent lady with a history of Fuchs heterochromic iridocyclitis with secondary glaucoma in the right eye since 2005 was diagnosed to have...