Cardiac manifestations of hypothyroidism are pericardial effusion, increased left ventricular dimension with left ventricular dysfunction, wall motion abnormality, asymmetric septal hypertrophy and mitral valve prolapse. Pericardial effusion occurs in 30-37% of cases and is mild to moderate but is occasionally large and cardiac tamponade is rare. We describe a case of hypothyroidism secondary t...

Chronic myelomonocytic leukaemia (CMML) is a myelodysplastic syndrome with a diverse clinical spectrum. A case of a 60 year old man with CMML who developed cardiac tamponade is reported. Cytological examination of the pericardial effusion fluid showed extramedullary haemopoiesis. Serous effusions are well recognised in association with this disease, but this seems to be the first reported case ...

Bedside lung ultrasound (LUS) is being adopted in ICUs, with a higher diagnostic accuracy for consolidation, interstitial syndrome, pleural effusion, and pneumothorax when compared chest radiography (CXR). Compare the performance of LUS CXR detection pathologic abnormalities critically ill patients ICU, using thoracic computed tomography (CT) as gold standard. Prospective descriptive single-cen...

Eosinophilic endomyocarditis is a manifestation of hypereosinophilic syndrome, characterized by prolonged (>6 months), unexplained peripheral blood eosinophilia (>1,500 cells/mm(3)) with end-organ damage in unknown causes. We report a case of a 42-year-old patient who developed eosinophilic endomyocarditis following upper respiratory tract symptoms for 2 months. Additionally, endomyocarditis wa...

RASSF1A gene, found at the 3p21.3 locus, is a tumor suppressor gene frequently hypermethylated in human cancers. In this study, we report that compared with melanocytes in normal choroid, RASSF1A is downregulated in uveal melanoma samples and in uveal melanoma cell lines. LOH at 3p21.3was detected in 50% of uveal melanoma. Moreover, methylation of the RASSF1A promoter was detected in 35 of 42 t...

PURPOSE Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor T-cell responses, the role of these treatments for metastatic uveal melanoma remains unclear. We sought to define the relative immunogenicity of th...

We describe a case of a 30 years old female patient who presented with nephrotic syndrome and impaired renal function diagnosed to have systemic lupus erythematosus (SLE). This is the first biopsy proven lupus nephritis in Tanzania. SLE is common among females and is reported be more common among Africans as compared to other races. This patient presented with nephrotic syndrome, pleural effusi...