BACKGROUND Calcium is the only reported dietary inhibitor of both heme- and nonheme-iron absorption. It has been proposed that the 2 forms of iron enter a common pool in the enterocyte and that calcium inhibits the serosal transfer of iron into blood. OBJECTIVES We aimed to ascertain whether the inhibitory effect of calcium occurs during initial mucosal uptake or during serosal transfer and t...

The intestine expresses metabolic enzymes and transporters and functions as a barrier to orally administered xenobiotics. This study aimed to examine the importance of multidrug resistance-associated protein 3 (Mrp3/Abcc3) in the serosal efflux of glucuronide conjugates formed in the intestine using wild-type and Mrp3(-/-) mice. The everted sacs of the intestine were incubated with 4-methylumbe...

The nature of the transmural electrical potential difference and the characteristics of water and electrolyte transport by rabbit esophagus were determined with in vivo and in vitro studies. The potential difference of the perfused esophagus in vivo was -28 +/- 3 mV (lumen negative). In vitro the potential difference was -17.9 +/- 0.6 mV, the short-circuit current 12.9 +/- 0.6 muA/cm2, and the ...

Primary tumors of the omentum are uncommon, and leiomyomas arising in the omentum are exceedingly rare. We report on a patient who presented with a large abdominal cyst presumed to be an omental cyst. At laparoscopy, after aspiration, the cyst was found to be attached to a solid mass arising from the greater omentum. The entire tumor was successfully excised laparoscopically. Histopathology an...

Isolated urinary bladders of the bullfrog (R. catesbeiana) and the toad (B. marinus) were mounted in an Ussing chamber. Potential differences up to 114 mv were observed in bullfrog bladder when the mucosal surface was bathed in dilute Na(2)SO(4) and the serosal surface in sulfate Ringer's. In experiments with bullfrogs, K was used to replace Na in the mucosal solution and Na was used for K in t...

The purpose of this study was to clarify the individual prognostic factors after curative and primary resection of hepatocellular carcinoma (HCC).Reliable prognostic factors and tumor staging for HCC have been required to predict an appropriate prognosis. However, in HCC, no staging system has received universal acceptance, and several tumor factors seem to relate to HCC prognosis, but they are...

Epidermoid cysts of the ovary are rare benign lesions and they are usually an incidental finding in hysterectomy specimens. We are presenting the largest reported case of an epidermoid cyst of the ovary which measured 17x10x10 cm, in a 50 year old lady with a preoperative diagnosis of a fibroid uterus.

1Shaheen, 2Seema Hakim, 3Veena Maheshwari, 4Smriti Bhargava 1Lecturer, Department of Obstetrics and Gynecology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India 2Professor, Department of Obstetrics and Gynecology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India 3Professor, Department of Pathology, JN Medical College, Aligarh Muslim Univer...

1. The transport of 6-thioguanine and 6-mercaptopurine has been studied with isolated jejunal loops of mouse small intestine. H.p.l.c. was used to identify and quantify the thiopurines and their metabolites in the serosal secretions. 2. When the lumen of the intestinal loops contained either 6-thioguanine or 6-mercaptopurine at a concentration of 1 mmol/l, the concentration of unmetabolized dru...

BACKGROUND The effect of thoracic epidural block on splanchnic blood flow is unclear. It remains to be resolved if sympathetic block, increases or decreases regional splanchnic blood flow and whether regional splanchnic flow becomes dependent on cardiac output or perfusion pressure. A clear understanding of the regional haemodynamic consequences of an epidural block may modify practice with res...