OBJECTIVE Urotensin II (UII) is a potent vasoactive peptide that binds to the urotensin receptor-coupled receptor-14 (known as UT) and exerts a wide range of actions in humans and experimental animals. We tested the hypothesis that UII gene deletion or UT blockade ameliorate experimental atherosclerosis. METHODS AND RESULTS We observed a significant reduction in weight gain, visceral fat, blo...

to ESRF. After 3 years of the initial diagnosis, the patient underwent autologous PBSC transplantation using intermediate dose melphalan (100mg/m). IgG level fell to 300mg/dl, with serum kappa free light chains of 83.2mg/l (3.3–19.4). Severe neutropenic sepsis precluded a planned second PBSC transplant. A year later, the patient underwent HLA-identical living donor kidney transplantation. Post-...