Operations research specialists at UPS and the Massachusetts Institute of Technology (MIT) created a system to optimize the design of service networks for delivering express packages. The system simultaneously determines aircraft routes, fleet assignments, and package routings to ensure overnight delivery at minimal cost. It has become central to the UPS planning process, fundamentally transfor...

We propose a novel method for mitigating erroneous wake-ups that are commonly associated with ultra-low power wake-up receivers. Recent research in low-power protocols has demonstrated significant improvements in energy-efficiency by employing ultralow power wake-up receivers. However, due to the low-complexity receiver structures adopted, wake-up receivers are susceptible to external interfere...

BACKGROUND Little evidence exists on the efficacy and safety of the different surgical techniques used in the treatment of postpartum haemorrhage (PPH). We aimed to compare uterus preserving surgery (UPS) versus hysterectomy for refractory PPH in terms of perioperative outcomes in a sub-Saharan African country with a known high maternal mortality ratio due to PPH. METHODS This was a retrospec...

Ubiquitination is a post-translational modification that plays a role in several cellular processes including cell cycle progression, cell proliferation, DNA replication and apoptosis. Ubiquitin-mediated signaling is frequently altered in cancer cells. Several tumor suppressors and oncogenes interact with enzymes of the ubiquitin-proteasome pathway that function in ubiquitin conjugation and dec...

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways, where abnormal UPS function has been observed in cancer and neurological diseases. Many neurodegenerative diseases share a common pathological feature, namely intracellular ubiquitin-positive inclusions formed by aggregate-prone neurotoxic proteins. This suggests that dysfunction of the UPS in neurodegenerat...

Since proteins play crucial roles in all biological processes, the finely tuned equilibrium between their synthesis and degradation regulates cellular homeostasis. Controlling the quality of proteome informational content is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas...

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Underground pedestrian systems (UPS) have been developed worldwide especially in the central areas of mega cities. They are integrated with subway systems, underground shopping streets and malls, and the basement of department stores in various forms and integrated with commerce, transport, retailing and public usage in urban functions. In cities with severe weather conditions such as Toronto a...

Plyometric research in the upper extremity is limited, with the effects of open-chain plyometric exercises being studied most. Kinematic and ground reaction force data concerning closed-chain upper extremity plyometrics has yet to be examined. Twenty-one recreationally active male subjects performed four variations of plyometric push-ups in a counterbalanced order. These included box drop push-...

Aggregation-prone proteins have been suggested to overwhelm and impair the ubiquitin/proteasome system (UPS) in polyglutamine (polyQ) disorders, such as Huntington's disease (HD). Overexpression of an N-terminal fragment of mutant huntingtin (N-mutHtt), an aggregation-prone polyQ protein responsible for HD, obstructs the UPS in cellular models. Furthermore, based on the accumulation of polyubiq...