Uninterruptible power supplies (UPS) play an important role in interfacing critical loads such as computers, communication systems, medical/life support systems, and industrial controls to the utility power grid. Among the various UPS topologies, on-line UPS provides the most protection to such loads against any utility power problem. However, because of the multiple power conversion stages, on...

Ubiquitin-proteasome system (UPS) is a multistep protein degradation machinery implicated in many diseases. In the nervous system, UPS regulates remodeling and degradation of neuronal processes and is linked to Wallerian axonal degeneration, though the ubiquitin ligases that confer substrate specificity remain unknown. Having shown previously that class IV dendritic arborization (C4da) sensory ...

This study aims at empirically investigating whether technology incubators help academic high-tech start-ups to establish collaborations with other organizations, thus increasing the competitiveness of these firms. In doing so, we take into account the specificities of academic hightech start-ups with respect to their non-academic counterparts. We compare the effects of incubation on academic a...

Uninterruptible power supply (UPS) systems are required for supplying sinusoidal output voltage for linear and nonlinear loads. They must be highly reliable and fast in dynamic response. Many control strategies have been applied to UPS inverters. The basic objectives of UPS control systems are tracking ability and robustness. Generally, the tasks of output voltage control for UPS inverters are ...

Mash-ups extract data fragments from disparate sources, and combine and transform the extracted fragments for display. Currently, mash-up developers tend to employ ad hoc representations for mash-up data, view mash-ups as applications, and use imperative scripts to extract and transform data fragments. These approaches can make mash-up development hard, and the mash-ups’ run-time performance po...

The ubiquitin-proteasome system (UPS) is responsible for turnover of most cellular proteins in eukaryotes. Protein degradation by the UPS serves quality control and regulatory functions. Proteasome inhibition showed great promise in effectively treating cancer and restenosis. UPS dysfunction in cardiac hypertrophy and failure has recently been suspected but remains to be investigated. A system ...

The ubiquitin proteasome system (UPS) degrades abnormal proteins and most unneeded normal proteins, thereby playing a critical role in protein homeostasis in the cell. Proteasome inhibition is effective in treating certain forms of cancer, while UPS dysfunction is increasingly implicated in the pathogenesis of many severe and yet common diseases. It has been previously shown that doxorubicin (D...

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system (UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective proteolytic system in which substrates are recognized and tagged with ubiquitin for processive degradation by the proteasome. Autophagy is a bulk degradative system that uses lysosomal hydrolases to degrade proteins as we...

We investigated the Ubiquitin-Proteasome System (UPS), major nonlysosomal intracellular protein degradation system, in the genesis of experimental postsurgical peritoneal adhesions. We assayed the levels of UPS within the adhered tissue along with the development of peritoneal adhesions and used the specific UPS inhibitor bortezomib in order to assess the effect of the UPS blockade on the perit...

The process of consolidating usability problems (UPs) is an integral part of usability evaluation involving multiple users/analysts. However, little is known about the mechanism of this process and its effects on evaluation outcomes, which presumably influence how developers redesign the system of interest. We conducted an exploratory research study with ten novice evaluators to examine how the...