نتایج جستجو برای: unfolding sequence

تعداد نتایج: 416116  

Journal: :Journal of molecular biology 1999
A R Dinner M Karplus

Simulations and experiments that monitor protein unfolding under denaturing conditions are commonly employed to study the mechanism by which a protein folds to its native state in a physiological environment. Due to the differences in conditions and the complexity of the reaction, unfolding is not necessarily the reverse of folding. To assess the relevance of temperature initiated unfolding stu...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1971
T Y Tsong R L Baldwin E L Elson

Temperature-jump studies have been used to detect a rapid reaction in the thermal unfolding of ribonuclease A (RNase A). The fast reaction occurs over a wide range of pH, and the results of a detailed study at pH 1.3 are reported here. Although its amplitude is small, the reaction is easily measurable over the entire temperature range of thermal unfolding. It occurs in the millisecond time rang...

Journal: :Angewandte Chemie 2021

Light-mediated coupling of acylsilanes with indoles is reported. This photo click reaction occurs under mild conditions (415 nm) mostly in quantitative yield and provides stable silylated N,O-acetals via light mediated siloxycarbene generation subsequent indole-N-H insertion. We show that this very efficient fully atom economic process can be applied to conjugate complex systems, as documented ...

2010
Greg Aloupis Prosenjit Bose Sébastien Collette Erik D. Demaine Martin L. Demaine Karim Douïeb Vida Dujmovic John Iacono Stefan Langerman Pat Morin

Abstract. This paper studies common unfoldings of various classes of polycubes, as well as a new type of unfolding of polyominoes. Previously, Knuth and Miller found a common unfolding of all tree-like tetracubes. By contrast, we show here that all 23 tree-like pentacubes have no such common unfolding, although 22 of them have a common unfolding. On the positive side, we show that there is an u...

2007
Robin Bergenthum Robert Lorenz Sebastian Mauser

We propose two new unfolding semantics for general Petri nets based on the concept of prime event structures. The definitions of the two unfolding models are motivated by algorithmic aspects. We develop a construction algorithm for both unfolding models. The unfolding models employ the idea of token flows developed in [JLD05] and are much smaller than the standard unfolding model. We show that ...

Journal: :Journal of molecular biology 2008
Lisa Green Chul-Hyun Kim Carlos Bustamante Ignacio Tinoco

The pseudoknot is an important RNA structural element that provides an excellent model system for studying the contributions of tertiary interactions to RNA stability and to folding kinetics. RNA pseudoknots are also of interest because of their key role in the control of ribosomal frameshifting by viral RNAs. Their mechanical properties are directly relevant to their unfolding by ribosomes dur...

2014
Yunxi Cui Deepak Koirala HyunJin Kang Soma Dhakal Philip Yangyuoru Laurence H. Hurley Hanbin Mao

Minute difference in free energy change of unfolding among structures in an oligonucleotide sequence can lead to a complex population equilibrium, which is rather challenging for ensemble techniques to decipher. Herein, we introduce a new method, molecular population dynamics (MPD), to describe the intricate equilibrium among non-B deoxyribonucleic acid (DNA) structures. Using mechanical unfold...

1996
Helmut Seidl

Deforestation is a transformation of functional programs to remove intermediate data structures. It is based on outermost unfolding of function calls where folding occurs when unfolding takes place within the same nested function call. Since unrestricted unfolding may encounter arbitrarily many terms, a termination analysis has to determine those subterms where unfolding is possibly dangerous. ...

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