نتایج جستجو برای: undercarboxylated osteocalcin

تعداد نتایج: 4017  

2014
Yan Jiang Zhen-Lin Zhang Zhong-Lan Zhang Han-Min Zhu Yi-Yong Wu Qun Cheng Feng-Li Wu Xiao-Ping Xing Jian-Li Liu Wei Yu Xun-Wu Meng

OBJECTIVE To evaluate whether the efficacy and safety of menatetrenone for the treatment of osteoporosis is noninferior to alfacalcidol in Chinese postmenopausal women. METHOD This multicenter, randomized, double-blinded, double-dummy, noninferiority, positive drug-controlled clinical trial was conducted in five Chinese sites. Eligible Chinese women with postmenopausal osteoporosis (N=236) we...

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Journal: :The Journal of Clinical Endocrinology & Metabolism 2011

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Journal: :Cell 2013
Franck Oury Lori Khrimian Christine A. Denny Antoine Gardin Alexandre Chamouni Nick Goeden Yung-yu Huang Hojoon Lee Prashanth Srinivas Xiao-Bing Gao Shigetomo Suyama Thomas Langer John. J. Mann Tamas L. Horvath Alexandre Bonnin Gerard Karsenty

The powerful regulation of bone mass exerted by the brain suggests the existence of bone-derived signals modulating this regulation or other functions of the brain. We show here that the osteoblast-derived hormone osteocalcin crosses the blood-brain barrier, binds to neurons of the brainstem, midbrain, and hippocampus, enhances the synthesis of monoamine neurotransmitters, inhibits GABA synthes...

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Journal: :Clinical chemistry 1993
P C Kao B L Riggs P G Schryver

We developed a competitive chemiluminoimmunoassay of osteocalcin that is similar to radioimmunoassay but uses acridinium-ester-labeled antigen instead of 125I-labeled osteocalcin; a second antibody immobilized on plastic beads is used to separate free and bound fractions. There was good correlation of the new chemiluminoimmunoassay (y) with a polyclonal antiserum (R102) radioimmunoassay (x) use...

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2012
Alexander Fisher Wichat Srikusalanukul Michael Davis Paul Smith

Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link between adipokines and osteocalcin. Materials and Methods. In a cross-sectional study of 294 older pati...

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2016
Laura J Lambert Anil K Challa Aidi Niu Lihua Zhou Janusz Tucholski Maria S Johnson Tim R Nagy Alan W Eberhardt Patrick N Estep Robert A Kesterson Jayleen M Grams

Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the skeleton, endocrine system, reproductive organs and central nervous system. However, differences between mouse and human osteocalcin at both t...

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Journal: :The Kobe journal of medical sciences 2014
Eriko Iwasaki Nuntana Morakote Somsak Chaovistsaree Hiroya Matsuo

The present study was carried out to investigate the influence of lifestyle on bone mineral density (BMD) and bone turnover among young women in Chiang Mai, Thailand. A total of 177 young women affiliated with Chiang Mai University hospital were enrolled. Firstly, questionnaires about their lifestyle and the Osteoporosis Knowledge Test (OKT) were examined. The measurement of BMD was assessed by...

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Journal: :Circulation 2006
Yibo Wang Weili Zhang Yuhui Zhang Yuejin Yang Lizhong Sun Shengshou Hu Jilin Chen Channa Zhang Yi Zheng Yisong Zhen Kai Sun Chunyan Fu Tao Yang Jianwei Wang Jing Sun Haiying Wu Wayne C Glasgow Rutai Hui

BACKGROUND The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on the formation of reduced-form vitamin K, a cofactor for gamma-carboxylation of vitamin K-dependent proteins, which is involved in the coagulation cascade and has a potential impact on atherosclerosis. We hypothesized that VKORC1-depende...

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Journal: :The British journal of nutrition 2012
Elke Theuwissen Ellen C Cranenburg Marjo H Knapen Elke J Magdeleyns Kirsten J Teunissen Leon J Schurgers Egbert Smit Cees Vermeer

Vitamin K is required for the carboxylation of Gla-proteins in the liver (coagulation factors) and extra-hepatic tissues, such as bone (osteocalcin, OC), and arterial wall (matrix Gla-protein, MGP). Although the coagulation factors are essentially fully carboxylated under normal conditions, 10-40 % of OC and MGP remains undercarboxylated. We were therefore interested to study the dose-response ...

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Journal: :The American journal of clinical nutrition 2010
Alan M Nevill Arthur D Stewart Tim Olds

REFERENCES 1. Nimptsch K, Rohrmann S, Kaaks R, Linseisen J. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr 2010;91: 1348–58. 2. Bolton-Smith C, Price RJ, Fenton ST, Harrington DJ, Shearer MJ. Compilation of a provisional UK database fo...

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