Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light. Herein, we evaluate the efficacy of NIR-PIT in a mouse model of disseminated peritoneal ovarian cancer. In vitro and in vivo experiments were conduct...

Introduction: The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) is expressed in the mammary gland and its overexpression induces profound phenotypic changes in proteins involved in cell proliferation, apoptosis, and invasion. Patients with breast cancer and elevated expression of Pit-1 show a positive correlation with the occurrence of distant metastasis. In this stu...

this study was carried out on olive trees cv. amygdalifolia, to investigate the effect of spraying potassium nitrate, kno3, and zinc sulfate, znso4, on the fruit weight, dimension and volume. the plants were sprayed with 0, 0.5, 1.0 and 1.5% kno3 and 0, 0.25, 0.50 and 0.75% znso4 and their combinations in august about halfway through the fruit growth period. the highest fruit weight was observe...

We discuss the fundamental limits of computing using a new paradigm for quantum computation, cellular automata composed of arrays of Coulombically coupled quantum dot molecules, which we term quantum cellular automata (QCA). Any logical or arithmetic operation can be performed in this scheme. QCA’s provide a valuable concrete example of quantum computation in which a number of fundamental issue...

In measurement practice, the concept resolution is usually associated with the ability to distinguish two overlapping components of the same kind in observations. The original concept, Rayleigh’s well-known two-point resolution, stems from optics. It is based on the presumed limits of the human visual system to distinguish the images of two closely located point sources in observations of the s...

1 1 Toronto Rehabilitation Institute. 439 University Avenue, Toronto, Ontario, M5G 1Y8, Canada. 2 Centre for Interprofessional Education, University of Toronto 3 Department of Occupational Science and Occupational Therapy, Faculty of Medicine, University of Toronto 4 Department of Physical Therapy, Faculty of Medicine, University of Toronto Correspondence: [email protected] Rec...

OBJECTIVE Radioimmunotherapy (RIT) has proven effective for patients with relapsed and refractory lymphoma. However, new types of therapy are strongly desired as B-cell lymphoma remains incurable for many patients. Photoimmunotherapy (PIT) is an emerging targeted cancer therapy that uses photosensitizer (IR700)-conjugated monoclonal antibodies (mAbs) to specifically kill cancer cells. To evalua...

Pituitary protein transcription factor (Pit-1) is a member of a large family of protein transcription factors that include Pit-1, Oct-1, Oct-2, and Unc-86. The goal of this experiment was to determine whether the population of Pit-1-containing cells changes in the anterior pituitary of chicken by the regulation of feeding. White Leghorn hens were subjected to withdrawal and resumption of feedin...