BACKGROUND AND OBJECTIVES To achieve better therapeutic benefits of local anesthetics in the control of postoperative pain through controlled-release carrier. The objective of this study was to compare the characteristics of sensory and motor blockade between microspheres without local anesthetic: racemic bupivacaine-loaded microspheres; 50% enantiomeric excess bupivacaine-loaded microspheres; ...

AIM Evaluation of bioelectrical impedance values and body composition during early infancy in groups of preterm newborns and full-term newborns. MATERIAL AND METHODS A total of 38 newborns was enrolled in the study: 26 very low birth weight preterm newborns with the mean birth weight of 1236 g (SD: 161) as the study group and 12 term newborns with birth weight of 2500-4000 g as the control gr...

almolookhiyeh (corchorus olitorius l.) known in the world as a valuable medicinal plant that was produced for the first time in iran in 2011. this study was aimed to quantify germination response of almolookhiyeh to temperature. for this purpose, seeds were exposed to different constant temperatures (10 ,15, 20, 25, 30, 35, 40, 45 and 50°c) in seed research lab, gorgan university of agricultura...

AIM To evaluate the efficacy and safety of a stainless steel miniature glaucoma drainage device (Ex-PRESS R50) for the surgical treatment of primary open angle glaucoma (POAG) and cataract when combined with phacoemulsification. METHODS Clinical, prospective, multicentre, single treatment arm, non-randomised, non-masked study. The Ex-PRESS device was implanted at the limbus under a conjunctiv...

Fu J, Kim J, Oveisi F, Astarita G, Piomelli D. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am J Physiol Regul Integr Comp Physiol 295: R45–R50, 2008. First published April 23, 2008; doi:10.1152/ajpregu.00126.2008.—Pharmacological administration of the natural lipid amide, oleoylethanolamide (OEA), inhibits food intake in...

Liposomal chemotherapeutics are exemplified by DOXIL® are commonly used in adult cancers. While these agents exhibit improved safety profile compared to their free drug counterparts, their treatment response rates have been ~ 20%, often attributed to the heterogeneous intratumoral uptake and distribution of liposomal nanoparticles. Non-invasive and quantitative monitoring of the uptake and dist...

When the PDD (percentage depth dose) in the megavoltage beams is measured in the water phantom using the dosimetry system, the polarity and ion recombination effects of ionization chambers with depth in water are not usually taken into consideration. The polarity and ion recombination effects may vary depending on the radiation type and spectrum, which vary with depth in water [1-4]. If those e...

RESUMO Araujo DR, Braga AFA, Moraes CM, Fraceto LF, Paula E – Mistura com Excesso Enantiomérico de 50% (S75-R25) de Bupivacaína Complexada com Ciclodextrinas e Anestesia por Via Subaracnóidea em Ratos JUSTIFICATIVA E OBJETIVOS: Com a finalidade de prolongar a duração de ação e reduzir a toxicidade sistêmica, têm-se desenvolvido formulações de anestésicos locais (AL) complexados com ciclodextrin...