An uncoupling protein (UCP) has been identified in mitochondria from Acanthamoeba castellanii, a nonphotosynthetic soil amoeboid protozoon that, in molecular phylogenesis, appears on a branch basal to the divergence points of plants, animals, and fungi. The existence of UCP in A. castellanii (AcUCP) has been revealed using antibodies raised against plant UCP. Its molecular mass (32,000 Da) was ...

The use case point (UCP) method is one of the most commonly used size estimation methods in software development. Applicability of UCP size for the project effort estimation is thoroughly investigated; however, little attention is devoted to the effort estimation of particular task types. The authors have created and cross-compared prediction models for estimating task-type efforts by means of ...

Serotonin (5-HT) is a central inhibitor of food intake in mammals. Thus far, the intracellular mechanisms for the effect of serotonin on appetite regulation remain unclear. It has been recently demonstrated that reactive oxygen species (ROS) in the hypothalamus are a crucial integrative target for the regulation of food intake. To investigate the role of ROS in the serotonin-induced anorexigeni...

Mitochondrial uncoupling protein (UcP) contains two tryptophans buried in transmembrane alpha-helices: Trp-173 at the matrix end of fourth alpha-helix and Trp-280 on the sixth alpha-helix. However, the steady-state emission of isolated UcP exhibited properties unusual for alpha-helices: maximum close to that of free tryptophan emission and low quantum yield of 0.04. The former suggests prevaili...

PPAR-α, PPAR-β, and PPAR-γ, and RXR in conjunction with PGC-1α and SIRT1, activate oxidative metabolism genes determining insulin sensitivity. In utero, hypoxia is commonly observed in Intrauterine Growth Restriction (IUGR), and reduced insulin sensitivity is often observed in these infants as adults. We sought to investigate how changes in oxygen tension might directly impact muscle PPAR regul...

By linearity, the above two questions are reduced to the unique continuation property (UCP) for the wave equation. Due to finite speed of propagation, the (UCP) holds only for T > 0 large enough and Ω will be supposed a connected domain. For instance, for a sufficiently smooth boundary, if T > 2max { dist (x, Γ) , x ∈ Ω}, then by Holmgren uniqueness theorem N = {u ∈ H (Ω× (0, T )) being a solut...

The effort to understand the mechanism of uncoupling by UCP has devolved into two models - the fatty acid protonophore model and the proton buffering model. Evidence for each hypothesis is summarized and evaluated. We also evaluate the obligatory requirement for fatty acids in UCP1-mediated uncoupling and the question of fatty acid affinity for UCP1. The structural bases of UCP transport functi...

THE WORD “AVATAR” (ævətar) is derived from the Sanskrit root word “avata ra,” which means “incarnation,” “manifestation,” “embodiment,” or “transformation” of someone in a different shape or form. Adipose tissue is a depot of fat (triglycerides) that serves as the body’s energy reserves in addition to functioning as an endocrine organ that synthesizes and secretes important metabolic regulatory...

There is evidence that user-centred development increases the user-friendliness of resulting products and thus the distinguishing features compared to products of competitors. However, the user-centred development requires comprehensive software and usability engineering skills to keep the process both cost-effective and time-effective. This paper covers that problem and provides insights in so...

Recently a novel technique has been published to augment traditional Branchand-Bound (B&B) while solving exactly a discrete optimization problem [Goldberg et al., 1997]. This technique is based on the negative thinking paradigm and has been applied to develop , a Unate Covering Problem (UCP) solver which reportedly was able to deal efficiently with some time-consuming benchmark problems. Howeve...