FAT10 is a ubiquitin-like modifier proposed to function in apoptosis induction, cell cycle control and NF-κB activation. Upon induction by pro-inflammatory cytokines, hundreds of endogenous substrates become covalently conjugated to FAT10 leading to their proteasomal degradation. Nevertheless, only three substrates have been identified so far to which FAT10 becomes covalently attached through a...

Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are proposed to counteract the post-translational modification of signaling molecules that activate the innate immune response. Here we examine the structural basis for PLpro's ubiquitin chain and interferon stimulated gene 15 (ISG15) ...

The BUZ/Znf-UBP domain is a protein module found in the cytoplasmic deacetylase HDAC6, E3 ubiquitin ligase BRAP2/IMP, and a subfamily of ubiquitin-specific proteases. Although several BUZ domains have been shown to bind ubiquitin with high affinity by recognizing its C-terminal sequence (RLRGG-COOH), it is currently unknown whether the interaction is sequence-specific or whether the BUZ domains...

A novel short-term wind energy forecasting method, which is being developed under the UBDIBM renewable energy modeling initiative, is described in this paper. The paper starts with a brief review on the existing forecasting methods. Prediction models based on the physical (derived from Numerical Whether Prediction models) and Time Series approaches are discussed. The prediction errors under the...

counts Ii)t' some island effcet (t;hc noun-coml~lemcnt ca',ms oi" Complex NP Consh':dnt) which is c.rre~:Lly unexplained by slatic approaches i:~ I, raditioua.] theories o1 syntax. This ex-']'he purpose of the present article, is to aceounI; for sy:itac tic constrai,:ts on some aspects of unborn:deal dependency (UBD he~'eafter) phenomeua, by means el a computational model. A COml)ul, a.donal mo...

INTRODUCTION A recent study of the pineal gland of the rat found that the expression of more than 3000 genes showed significant day/night variations (The Hartley dataset). The investigators of this report made available a supplemental table in which they tabulated the expression of many genes that they did not discuss, including those coding for components of the ubiquitin proteasome system. He...

BACKGROUND Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have been demonstrated to result in an antiviral state within the host cell. Transcriptome profiling was conducted on Huh-7 human hepatoma cells bearing subgenomic HCV replicons with...

Analysis of the drilling fluid temperature due to heat transfer of drilling fluid with the formation in under-balanced drilling operation is the main objective of this study. Gas-liquid two-phase flow model considering thermal interaction with the formation is used to numerically simulate a well with real dimensions. In the present study, the continuity, momentum, and energy equations are devel...

(98) Eleiotis DC. (1825) [Angiosp.: Legum.] Eleotis Ver.-Lib. & R.D. Stone (2020) Melastomat.] The genus was first established by the Swiss botanist Augustin Pyramus de Candolle (Prodr. 2: 348. Nov 1825) with monophylla (l.c.) (the epithet taken from illegitimate Glycine monophyllos Burm. f., Fl. Ind.: 161. 1768, non L. 1767) and E. sororia (L.) (≡ Hedysarium sororium L., Mant. Pl. Alt.: 270. 1...