نتایج جستجو برای: type of opioid
تعداد نتایج: 21262139 فیلتر نتایج به سال:
OBJECTIVES Opioids have been used for medicinal and analgesic purposes for centuries. However, their negative effects on the endocrine system, which have been known for some times, are barely discussed in modern medicine. Therefore, we conducted a systematic review of the impact of opioids on the endocrine system. METHODS A review of the English language literature on preclinical and clinical...
Nociceptin/orphanin FQ (N/OFQ), a 17-amino-acid peptide, is an endogenous agonist whose receptor is similar in sequence to mu, delta and kappa opioid receptors. It has been reported that N/OFQ can block antinociceptive effects induced by opioid receptor agonists in the radiant heat tail-flick test and warm water tail-withdrawal test. The present study was designed to see the effect of N/OFQ on ...
Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (A, y, n) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 jC hotplate in adult, femal...
Dual-acting kappa opioid receptor (KOR) agonist and mu opioid receptor (MOR) partial agonist ligands have been put forward as potential treatment agents for cocaine and other psychostimulant abuse. Members of the orvinol series of ligands are known for their high binding affinity to both KOR and MOR, but efficacy at the individual receptors has not been thoroughly evaluated. In this study, it i...
چکیده تمام نما مقدمه: این تحقیق برای بررسی میزان خلاقیت و عناصر آن (انعطاف- سیالی- ابتکار و بسط) در کارشناسان فوق برنامه های تربیت بدنی دانشگاههای تهران صورت گرفته است. بطور کلی خلاقیت به معنای توانایی تولید اندیشه ها و ایده های جدید و ترکیب آنها با یکدیگر و بیشتر در جنبه های فکری نظری و به اصطلاح فعالیتهای ذهنی و طراحی قبل از عمل به کار می رود و دارای چهار عنصر به شرح زیر می باشد. 1- سیالی...
tics are sudden, recurrent and stereotyped motor movements or vocalizations. dopamine blockers are the main pharmacological agents used in the management of tics. opioid antagonists have been reported to have been effective in the management of tics. in this article, two patients with chronic motor tic disorder are reported, whose symptoms were disappeared by using opioid substances.
The Opioid Growth Regulatory System consists of opioid growth factor (OGF), [Met5]-enkephalin, and its unique receptor (OGFr). OGF inhibits cell division when bound to OGFr. Conversely, blockade of the interaction of OGF and OGFr, using the potent, long-acting opioid receptor antagonist, naltrexone (NTX), results in increased DNA synthesis and cell division. The authors have demonstrated both i...
هدف اصلی ما در این پایان نامه، مطالعه عملگردهای مثبت و نگاشت های حالت روی * – جبرهای باناخ و –c* جبرها می باشد. در وهله بعدی *- ایزومورفیسم های بین –c* جبرهای یکدار را مورد مطالعه قرای می دهیم . علاوه بر موارد فوق، پایداری –j* مشتقها روی –j* جبرها را به عنوان کاربردی از قضیه نقطه ثابت تعمیم یافته مورد مطالعه قرار می دهیم و نهایتا با پیدا کردن حل عمومی برای معادله تابعی ترکیبی چهارتایی جمعی، درج...
Spinocerebellar ataxia type 23 is caused by mutations in PDYN, which encodes the opioid neuropeptide precursor protein, prodynorphin. Prodynorphin is processed into the opioid peptides, a-neoendorphin, and dynorphins A and B, that normally exhibit opioid-receptor mediated actions in pain signalling and addiction. Dynorphin A is likely a mutational hotspot for spinocerebellar ataxia type 23 muta...
conclusions the results showed that having an addicted husband could strongly affect some sexual domains in women. it could change the pattern of desire and motivation for sexual contact in females and alter their attitude toward the sexual relationship, thereby causing disturbances in the females’ normal sexual function. results according to the results, the frequency of hypoactive sexual desi...
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