We hypothesize tha t prostacyclin (PG I2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial P G I2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, P G I2 generation is im paired in atherosclerosis, and infusion of synthetic P ...

The necessity of the inclusion second invariant left Cauchy-Green deformation tensor B, namely I2, in strain energy function W rubber-like materials is analysed. Universal relationships that underline such are revisited, and experimental data examined to establish trends variation ?W/?I2. Corroborated by established trends, we consider (meso)structural arguments devise a plausible approach for ...

We report a new type of photofragment caging reaction that is only possible because of the strong solvent-induced perturbation of the inherent electronic structure of the chromophore. The photoexcitation of I2 2 at 395 nm promotes it to a dissociative state correlating with I1I*(P1/2), the only near-ultraviolet dissociation channel for unsolvated I2 . In I2 ~CO2!n and I2 ~OCS!n clusters, intera...

OBJECTIVE We conducted a systematic review and meta-analysis of previous observational epidemiologic studies examining the relationship between residential pesticide exposures during critical exposure time windows (preconception, pregnancy, and childhood) and childhood leukemia. DATA SOURCES Searches of MEDLINE and other electronic databases were performed (1950-2009). Reports were included i...

The enzyme UGT2B7 is one of the most active UDP-glucuronosyltransferases (UGTs) involved in drug metabolism and in maintaining homeostasis of endogenous compounds. We recently reported the existence of 22 UGT2B7 mRNAs, two with a classic 59 region but alternative 39 ends namely UGT2B7_v5 (containing a novel terminal exon 6b) and _v7 (exon 5 excluded) that encode enzymatically inactive isoforms ...

BACKGROUND We explored the role that inhibitory heterotrimeric G-proteins play in ventricular arrhythmia. METHODS AND RESULTS Mice with global genetic deletion of Galpha(i2) [Galpha(i2) (-/-)] were studied and found, based on telemetry, to have a prolonged QT interval on surface ECG when awake. In vivo electrophysiology studies revealed that the Galpha(i2) (-/-) mice have a reduced ventricula...

Abstract Background The use of catheter-based thrombolysis in comparison to systemic thrombolytics has emerged as a potentially lifesaving therapy for patients with sub massive or pulmonary embolism (PE). addition ultrasound waves accelerate lytic dispersion assisted (USAT) been proposed improve outcomes compared standard catheter-directed (SCDT). These two modalities have small studies, but la...

Bitter taste perception is a conserved chemical sense against the ingestion of poisonous substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called TAS2R or TRB) receptors and a G-protein alpha subunit (Galpha), gustducin, are believed to be key molecules for its perception, but little is known about the molecular basis for its interaction. Here, we use a heterolog...

Let i1 ≥ i2 ≥ i3 ≥ 1 be integers. An L(i1, i2, i3)-labelling of a graph G = (V, E) is a mapping φ : V → {0, 1, 2, . . .} such that |φ(u)− φ(v)| ≥ it for any u, v ∈ V with d(u, v) = t, t = 1, 2, 3, where d(u, v) is the distance in G between u and v. The integer φ(v) is called the label assigned to v under φ, and the difference between the largest and the smallest labels is called the span of φ. ...

We report the dispersed fluorescence spectra of the linear and the previously well-studied T-shaped isomers of Ar–I2 following B←X optical excitation for vpump516– 26, below the I2 dissociation limit. The linear isomer has a continuum excitation spectrum. For excitation at the highest pumping energy (vpump526), the product vibrational state distribution is nearly identical to that observed for ...