Background: The protein of Niemann-pick type C1 (NPC1) gene promotes the egress of cholesterol from late endosomes and lysosomes to other cellular compartments and contributes to a process known as reverse cholesterol transport. This study aimed to examine whether promoter methylation of NPC1 is associated with risk of cardiovascular disease (CVD). Methods: Fifty CVD patients and 50 healthy sub...

“T-fold” backgrounds are generically-nongeometric compactifications of string theory, described by T fibrations over a base N with transition functions in the perturbative T-duality group. We review Hull’s doubled torus formalism, which geometrizes these backgrounds, and use the formalism to constrain the D-brane spectrum (to leading order in gs and α ) on T fibrations over S with O(n, n;Z) mon...

Screening mammography has been successful in early detection of breast cancer, which has been one of the leading causes of death for women worldwide. Among commonly detected symptoms on mammograms, mass detection is a challenging problem as the task is affected by high complexity of breast tissues, the presence of pectoral muscles as well as varying shape and size of masses. In this research, a...

BACKGROUND/AIM To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalovirus immediate early promoter enhancer (CMV). MATERIALS/METHODS Enhanced TK-EGFP expression was confirmed by fluorescent microscopy, real time PCR and telomerase activity....

We introduce two-dimensional vector boson oscillator (VBO) by using the generalized equation that derived as an excited state from canonical quantization of classical spinning particle with Zitterbewegung. write relativistic (VBE) and coupling through non-minimal substitutions. This form is linear in both momentum coordinate. The corresponding gives a set coupled equations. By solving these equ...

Glycogen storage disease type II (Pompe disease) causes death in infancy from cardiorespiratory failure due to acid alpha-glucosidase (GAA; acid maltase) deficiency. An AAV2 vector pseudotyped as AAV6 (AAV2/6 vector) transiently expressed high-level human GAA in GAA-knockout (GAA-KO) mice without reducing glycogen storage; however, in immunodeficient GAA-KO/SCID mice the AAV2/6 vector expressed...

Size Functions and Support Vector Machines are used to implement a new automatic classifier of melanocytic lesions. This is mainly based on a qualitative assessment of asymmetry, performed by halving images by several lines through the center of mass, and comparing the two halves in terms of color, mass distribution, and boundary. The program is used, at clinical level, with two thresholds, so ...

The DF3/MUC1 gene is aberrantly overexpressed in human breast and other carcinomas. Previous studies have demonstrated that the DF3/MUC1 promoter/enhancer confers selective expression of diverse transgenes in MUC1-positive breast cancer cells. In this study, we show that an adenoviral vector (Ad.DF3-E1) in which the DF3/MUC1 promoter drives expression of E1A selectively replicates in MUC1-posit...