Both TWIST and the endothelin-1 (ET-1)/endothelin A receptor (ETAR) signaling are important in osteosarcoma (OS) progression. In the present study, the interaction between TWIST and ET-1/ETAR signaling in OS cells was investigated, and the impact of the functional interaction on OS cell survival against chemotherapy agent-induced apoptosis was assessed. TWIST was overexpressed and knocked down ...

Problem statement: The objective of this study is to compare the methods for approximating the positions of twist fiber in yarn structures. Computer Aided Design (CAD) is applied using parametric equation, spline curve and NURBS curve. The ideal twist fiber and fiber migration are studied in 3 dimensions. Approach: The fiber positions in yarn structures were measured by trace fiber technique. T...

In wide kinematic regions the deeply inelastic structure functions can be described by their leading twist contributions within Quantum Chromodynamics (QCD). Higher twist corrections [1] emerge both in the region of large [2,3] and small values [4,5] of the Bjorken variable x. The leading twist sector, both for unpolarized and polarized deeply inelastic scattering, is well explored within pertu...

Myofibril shortening and the oblique fiber orientation of the left ventricular myocardium results in a twisting motion of the left ventricle. Advances in cardiac magnetic resonance imaging (MRI) have made it possible to label the myocardium noninvasively and track this motion (twist) through the cardiac cycle, but little data exist on its complete systolic time course. The purpose of this study...

The cancer stem cell paradigm postulates that dysregulated tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Consequently, identifying cancer stem cells is crucial to our understanding of cancer progression and for the development of novel therapeutic agents. In this study, we demonstrate that the overexpression of Twist in breast cells can promote the generat...

Androgen-independent metastatic prostate cancer is the main obstacle in the treatment of this cancer. Unlike a majority of solid cancers, prostate cancer usually shows poor response to chemotherapeutic drugs. In this study, we have shown a potential novel target, TWIST, a highly conserved bHLH transcription factor, in the treatment of prostate cancer. Using malignant and nonmalignant prostate t...

YB-1 controls gene expression through both transcriptional and translational mechanisms and is involved in various biological activities such as brain development, chemoresistance, and tumor progression. We have previously shown that YB-1 is overexpressed in cisplatin-resistant cells and is involved in resistance against DNA-damaging agents. Structural analysis of the YB-1 promoter reveals that...

During incremental exercise, stroke volume (SV) plateaus at 40-50% of maximal exercise capacity. In healthy individuals, left ventricular (LV) twist and untwisting ("LV twist mechanics") contribute to the generation of SV at rest, but whether the plateau in SV during incremental exercise is related to a blunting in LV twist mechanics remains unknown. To test this hypothesis, nine healthy young ...