Tumor immunotherapy is currently a hot research topic in the field of oncology, and an efficacious mode tumor treatment. Programmed cell death receptor PD-1 (PD-1) important immunosuppressive molecule, which mainly expressed activated T B cells. PD-1/PD-L1 inhibitors can block binding to PD-L1, negative regulatory signals, restore activity cells, thus enhancing immune response.

Introduction: Epidermal growth factor receptor (EGFR) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. In the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. Methods: In this study using m13-PVIII phage display system, two constructs we...

Background: Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer. Objective: To evaluate the effects of C. albicans structural and secreted proteins on intratumoral CD4/CD8 ratio as well as the survival rate in BALB/c t...

background: ovarian cancer comprises a heterogeneous group of neoplasms. the prognosis cannot be predicted by histopathologic examination alone. the aim of this study is to evaluate p53, pten, and β-catenin expressions in primary ovarian carcinomas in an attempt to find a possible relationship with morphologic parameters and clinical findings. methods: the study included 100 epithelial ovarian ...

Nanoenzymes In article 2300191 by Wenli Diao, Hui Wei, Hongqian Guo, and co-workers, a Zr-CeO nanozyme is developed to possess enhanced activities mimicking superoxide dismutase catalase. Via scavenging intracellular reactive oxygen species, exerts remarkable effects on diminishing myeloid-derived suppressor cells M2-TAM immunosuppression simultaneously, eventually boosts anti-tumor immune resp...

Background: Dendritic cells (DCs) contribute essentially to the outset and course of immune responses. So in patients with malignancy, there have been considerable interests in use of these cells in different interventions. Objective: To evaluate the impact of Leishmania major’s components on DC maturation and their use as a therapeutic agent against t...