Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...

The tumor microenvironment (TME) is an intricate ecosystem that actively involved in various stages of cancer occurrence and development. Some characteristics biological behavior, such as proliferation, migration, invasion, inhibition apoptosis, immune escape, angiogenesis, metabolic reprogramming, are affected by TME. Studies have shown non-coding RNAs, especially long-chain RNAs microRNAs can...

Abstract Oil from Nigella sativa seeds (“black seed oil”) has been used for health care and medical purposes over 2000 years. The major active compound thymoquinone (TQ) shown to have immune regulatory effects in various diseases. Tumor microenvironment is critical tumor development. Immune cells, particularly T are central players kill cells affect progression metastasis. impact of TQ on human...

In this paper, we study the effect of time delays on dynamics angiogenesis tumor growth. The represent taken for mitosis. model is based reaction-diffusion equation described in form concentration nutrients $ \sigma and distribution internal pressure p caused by movement cells. vasculature supplies to tumor, so that \frac{\partial\sigma}{\partial {\bf{n}}}+\beta(\sigma-\bar{\sigma}) = 0 holds b...

Conventional chemotherapy targets proliferating cancer cells, but most cells in solid tumors are not in a proliferative state. Thus, strategies to enable conventional chemotherapy to target noncycling cells may greatly increase tumor responsiveness. In this study, we used a 3-dimensional tissue culture system to assay diffusible factors that can limit proliferation in the context of the tumor m...

Conventional chemotherapy targets proliferating cancer cells, but most cells in solid tumors are not in a proliferative state. Thus, strategies to enable conventional chemotherapy to target noncycling cells may greatly increase tumor responsiveness. In this study, we used a 3-dimensional tissue culture system to assay diffusible factors that can limit proliferation in the context of the tumor m...

As the major cell surface receptors for extracellular matrix, integrins regulate adhesion and migration, have been shown to drive tumor growth progression. Our earlier findings identified integrin α3β1 as a key regulator of keratinocyte secretome skin microenvironment, indicating its potential efficacy therapeutic target. Previous mass spectrometric analysis conditioned medium from immortalized...

Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation further modifications cell behavior, which critical for tumor progression. Angiogenesis therapeutic resistance known to be modulated by hypoxia other microenvironments, such as acidic stress, both core features glioblastoma microenvironment. Hypoxia has also been shown pro...

The choice of lung cancer treatment method directly depends on the diagnostisc and verification histological type tumor. Important diagnostic criteria are DNA accumulation index proliferation Ki-67. Materials methods. was assessed in 200 cases using a microspectrophotometric method. Ki-67 proliferative calculated immunohistochemical study material with antibodies to Ki-67, Cytokeratin 5/6, TTF-...