Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...

Aim. To estimate the concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (interleukin, IL-6), vascular endothelial growth factor (VEGF) in blood serum and to analyze polymorphism TNF-α cytokine genes region 308G / A (rs1800629), IL-6 174G C (rs1800795) VEGFA 634G (rs2010963) patients with chronic diffuse liver diseases (CDLD) living Perm region. Materials methods. In 193 CDLD 90...

Abstrak Diabetes mellitus tipe 2 berkaitan dengan adanya kondisi inflamasi ringan vaskuler. Kadar tumor necrosis factor-α (TNF-α) yang meningkat berhubungan sitokin dan resiko komplikasi dari diabetes melitus 2. TNF-α, metabolit nitric oxide (NO) menandakan disfungsi endotel pada Melitus Hal ini akan mengakibatkan kadar CRP penderita juga meningkat. merupakan indikator kerusakan jaringan tubuh....

BACKGROUND/AIMS It has been shown that circulating tumor necrosis factor α (TNF-α) is elevated in end stage renal disease patients; however, the relationship between TNF-α and the development of infection in these patients is unknown. In this study, we investigated the association of plasma TNF-α and interleukin 6 (IL-6) with infection in peritoneal dialysis (PD) patients. We also evaluated the...

BACKGROUND:Purple sweet potato tuber ethanol extract (PSPTEE) has been known to have benefits in various disease, including prevent nasopharyngeal carcinoma (NPC). However, there no research on PSPTEE preventing the proliferation of mucosal epithelial cells induced by formaldehyde through oxidative stress mechanisms and inflammatory process. Studies proven effect PSP cancer cells, but carcinoge...

Background Infertility is a problem concerning 10-15% of the individuals in the fertile period. This study investigated effects of proinflammatory factors as well as lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success. MaterialsAndMethods In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before (gr...

Nowadays, Stroke is regarded as the second major cause of death and third morbidity globally. The ischemic stroke (IS) among most fatal kind strokes. Thus, due to importance this subject, article aims analyze role fibrosis markers (matrix metalloproteinase-9, tissue inhibitor matrix metalloproteinases-1), cytokines (tumor necrosis factor-α, interferon-γ, monocytic chemoattractant protein-1) in ...

Tumor necrosis factor-α (TNF-α) blockers are a popular therapeutic choice in a number of inflammatory diseases. Thus far, five TNF- α blockers have been approved for clinical use (etanercept, infliximab, adalimumab, golimumab. and certolizumab). Despite being considered relatively safe, serious side effects associated with immune suppression have been reported, including central and peripheral ...

Introduction:To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME) Materials and Methods:We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy contr...

Background.  Histoplasmosis causes severe disease in patients with defects of cell-mediated immunity. It is not known whether outcomes vary related to the type of immunodeficiency or class of antifungal treatment. Methods.  We reviewed cases of active histoplasmosis that occurred at Vanderbilt University Medical Center from July 1999 to June 2012 in patients with human immunodeficiency virus (H...