Surgery represents the mainstream therapeutic modality in oncology. Aggressive radical surgery to achieve no residual tumor would improve survival, which is mainly affected by vascular involvement and accuracy of judging negative margin resection. However, there currently intraoperative tool that can simultaneously perform microscopic analysis peritumoral vasculature vivo surgical pathology ex ...

introduction bronchial adenoma is rare in primary tumors of the lung and produce non-specific respiratory symptoms. case presentation a 4-year-old boy referred to our clinic with chronic cough and wheezing. foreign body aspiration was recommended for him on the base of radiologic and clinical manifestation. in bronchoscopy, foreign body was not detected, but an obstructing tumor was found at le...

Histologic patterns at tumor margins may be related to prognosis in several malignancies. We investigated tumor aggressiveness with respect to tumor margin histology in patients with papillary thyroid carcinoma (PTC). Five hundred fourteen consecutive patients who underwent surgery for primary PTC between January and July 2009 were assigned to two groups, one with an infiltrative pattern (I-typ...

PURPOSE To determine whether conventional contrast-enhanced computed tomography (CT) could be used to identify imaging phenotypes associated with a doxorubicin drug response gene expression program in hepatocellular carcinoma (HCC) by using an integrated imaging-genomic approach. MATERIALS AND METHODS Thirty HCCs were analyzed and scored individually across six predefined imaging phenotypes. ...

BACKGROUND The aims of the study are three-dimensional analysis of mode and distance of local spread of oral tongue carcinoma. METHODS The glossectomy specimens were examined in the coronal plane in 3 mm thickness section. RESULTS There were 50 glossectomy specimens. The maximum spread was 1.8 cm. Ninety-six percent of specimens had local spread within 1.2 cm. The distance of spread was not...

The tumor microenvironment is known to play a critical role in tumor progression, invasion and metastasis. The epithelial-to-mesenchymal transition (EMT) is understood as a process of tumor invasion and metastasis. Therefore, we investigated the relation between the EMT and the microenvironment of colorectal carcinoma (CRC). The histological features and expression of EMT markers in tumor cells...

Intraoperative frozen section (FS) evaluation of ureteral and urethral margins is frequently requested during radical cystoprostatectomy in patients with bladder urothelial carcinoma. However, it is still controversial whether intraoperative FSs of ureteral and urethral margins are necessary in all patients with cystoprostatectomy or a risk-based assessment with limited to the high risk patient...

Osteosarcoma is a rare malignant tumor of the maxilla. Although clear surgical margin is the only predictor for the prognosis of the disease, neoadjuvent chemotherapy showed a reasonable effect on the tumor with variable degree of necrosis. In this article, we report two cases where neoadjuvent chemotherapy was used with review of the literature.

Fig.2: Hydrophilic spectra of glioma tissue (0.8 – 4.6 ppm). Top: tumor margin; Bottom: tumor core (Ala=Alanin, Cr=creatine, GPCho=glycerophosphocholine, Gln=glutamine, Glu=glutamate, Gly=glycine, Ile=isoleucine, Ino= Inositol, Lac=lactate, Leu=leucine, NAc=N-acetyl, PCho=phosphocholine, PCr=phosphocreatine, Succ=succinate, Tau=taurine, Val=valine) Lactate 3 Cr(CH3)/GABA 4 CLASSIFICATION ON EX-...