Magnetic hyperthermia (MH) harnesses the heat-releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune activation in tumor microenvironment whilst sparing surrounding normal tissues. To assess feasibility localized MH vivo, SPIONs are injected intratumorally their fate tracked by Zirconium-89-positron emission tomography, histological ana...

Usp9x has emerged as a potential therapeutic target in some hematologic malignancies and a broad range of solid tumors including brain, breast, and prostate. To examine Usp9x tumorigenicity and consequence of Usp9x inhibition in human pancreatic tumor models, we carried out gain- and loss-of-function studies using established human pancreatic tumor cell lines (PANC1 and MIAPACA2) and four spont...

background: neuroblastoma is the most common tumor in infancy and wilms’ tumor is the most common malignant tumor of kidney in childhood. both the tumors are usually within the differential diagnosis of each other. this study compares the clinical manifestations, sex and age distribution of childhood wilms’ tumor and neuroblastoma at one of tehran children hospitals. materials and methods: the ...

abstract gastrointestinal mesenchymal tumors are a group of tumors originating from the mesenchymal stem cells of the gi tract. digestive tract schwannomas are rare mesenchymal tumors which occur most frequently in the stomach. we report a 56-yearold woman who was examined endoscopically for dyspepsia which she had suffered from since 3 years ago. around gastric antral mass was seen. surgical r...

Modern cancer immunotherapies largely focus on the ability of CD8+ cytolytic T cells to directly recognize and kill tumor cells. These strategies are limited by development an immunosuppressive microenvironment emergence immune evasive MHC-deficient or IFN-unresponsive CD4+ effector can contribute responses independent However, potential mechanisms cell-mediated anti-tumor immunity remain elusi...

The tumor hypoxic microenvironment not only induces genetic and epigenetic changes in cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On other hand, conventional approaches which kill cells or destroy blood to block nutrition supply usually facilitate even harsher microenvironment. Thus, simultaneously relieving strained res...