Sera were collected from 111 patients diagnosed with adenocarcinoma or nonadenocarcinoma malignancies who received different schedules of interferon (IFN)-gamma or IFN-beta ser alone or in combination. Serum carcinoembryonic antigen (CEA) and tumor-associated glycoprotein-72 (TAG-72) antigen levels were measured to determine whether interferon could enhance the tumor shedding and, thereby, the ...

MUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon cancer. This trial provided a unique source of potentially effective and safe immunotherapeutic drugs, fully-human antibodies affinity-matured in a healthy host to a tumor antigen. We pur...

Cancer immunotherapy refers to any intervention that leverages the immune system to eliminate a malignancy. Successful cancer immunotherapies generate an anti-cancer response that is systemic, specific, and durable and overcome to the primary limitations of traditional cancer treatment modalities. In this review paper, the effective methods in immune system to treat cancer, such as immunosuppre...

Abstract The tumor microenvironment is highly immunosuppressive, allowing cancer to evade the immune system by inducing dysfunction, exhaustion, or subversion of CD8+ T-cell functions. Cancer immunotherapies using attenuated strains Listeria monocytogenes (Listeria) engineered express antigens have been demonstrated promote antigen-specific T-cells that infiltrate and control mouse models cance...

Tumor-associated transplantation antigen (TATA) was found to be present in fractions derived from the cytosol of the Meth A cell. Meth A ascites cells were disrupted, nuclei and mem branes were removed by lowand high-speed centrifugation, and the soluble protein was fractionated by ammonium sulfate precipitation and gel filtration chromatography. The TATA of the soluble cytosol fractions appear...

OBJECTIVE To study changes of tumor associated carbohydrate antigen (TACAs) expression and mRNA levels for tumor associated glycosyltransferases, and assess subcellular localizations of N-acetyl galactosyltransferases (GalNAc-Ts) in the K562 leukemia cell line after imatinib treatment. METHODS RT-PCR was performed to analyze the expression of glycosyltransferases which synthesize O-glycan in ...

Modern cancer immunotherapies largely focus on the ability of CD8+ cytolytic T cells to directly recognize and kill tumor cells. These strategies are limited by development an immunosuppressive microenvironment emergence immune evasive MHC-deficient or IFN-unresponsive CD4+ effector can contribute responses independent However, potential mechanisms cell-mediated anti-tumor immunity remain elusi...