Abstract Background Disseminated Mycobacterium marinum infections occur rarely, in immunocompromised patients. Treatment with a prolonged multi-drug regimen exposes patients to drug–drug interactions and side effects. Case report We case of disseminated M. infection 54-year-old renal transplant, HIV-infected woman. Manifestations the were cutaneous subcutaneous nodules, mediastinal lymph nodes ...

BACKGROUND Non- Tuberculous Mycobacteria are environmental opportunistic pathogens that can be found in various terrestrial and aquatic habitats. There are an epidemiological links between species isolated in tap water and those isolated from patients. hsp65 gene has more variability in its sequences, compared to the some more conserved genes in NTM, for identification of mycobacteria to specie...

Free-living protozoa allow horizontal gene transfer with and between the microorganisms that they host. They host mycobacteria for which the sources of transferred genes remain unknown. Using BLASTp, we searched within the genomes of 15 mycobacteria for homologous genes with 34 amoeba-resistant bacteria and the free-living protozoa Dictyostelium discoideum. Subsequent phylogenetic analysis of t...

Rapidly growing mycobacteria are non-tuberculous mycobacteria amply present in the environment. Although they are not usually pathogenic for humans, they are opportunistic in that they can cause disease in people with disadvantageous conditions or who are immunocompromised. Mycobacterium peregrinum, an opportunistic, rapidly growing mycobacteria, belongs to the M. fortuitum group and has been r...

The search for factors that account for the reproduction and survival of mycobacteria, including vaccine strains, in host cells is the priority for studies on tuberculosis. A comparison of BCG-mycobacterial loads in granuloma cells obtained from bone marrow and spleens of mice with latent tuberculous infection and cells from mouse bone marrow and peritoneal macrophage cultures infected with the...

BACKGROUND WHO recommends Xpert MTB/RIF as initial diagnostic testing for tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about 50-70% and culture sensitivity of about 60%. We evaluated the diagnostic performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis. METHODS We prospectively obtained diagnostic cerebrospinal fluid (CSF...

An outstanding feature of the phenomenon of acquired immunity in tuberculosis is the lack of multiplication of virulent mycobacteria in the tissues of the immunized host. As the result, viable, virulent, tubercle bacilli may remain dormant in vivo for long periods of time. The nature of the acquired specific mechanism responsible for this bacteriostasis in vivo has never been determined althoug...

OBJECTIVE To compare three methods: Biochemical tests, high-performance liquid chromatography (HPLC) and polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP), for the identification of mycobacteria, and to perform a cost-benefit analysis to define an optimum identification algorithm. MATERIAL AND METHODS One-hundred-and-seven mycobacteria isolates were identified by ...

In veterinary medicine the increasing attentions have been paid to the potential role of atypical mycobacteria as opportunist pathogens in animal health as a result of the successful contl'ol of bovine tuberculosis, as reviewed by Kazdall. This tendency will be partially explained from the fact that one is tempted to interpret the occuHence of the so-called no visible lesion reactors, a very pe...