OBJECTIVE Because of the disparity between the recommendations regarding age and frequency for the realization of tuberculin testing during childhood, a study of tuberculous infection prevalence according to age was made in order to establish at which ages tuberculin testing would be recommendable and to determine if there is a difference in prevalence between vaccinated and non-vaccinated chil...

We have previously reported the results of ten years of systematic tuberculin Qsting of kindergarten and first grade children in Kansas City, Missouri. This report adds seven yeas of testing in different age groups (8th and 9th; and 4th and 5th grades). As reported in the previous study, the prevalence rates and conversion rates to tuberculin are markedly different depending on the frequency at...

1. When toxic filtrates from cultures of B coli, B. typhosus, or meningococci are injected into the blood stream, peritoneal cavity, or subcutaneous tissue of tuberculous guinea pigs, the skin at the site of a tuberculin reaction becomes hemorrhagic. The extent of the hemorrhage is proportional to the severity of the tuberculin reaction demonstrable by tests with various dilutions of tuberculin...

This study was aimed to develop a dry purified protein devirative (PPD) preparation to extend the shelf-life of tuberculin PPD. Five percent sucrose (S), 6.5% mannitol (M), 2.5% trehalose (T) or 0.3% Hemaccel (H) was added to each formulation. In vivo and in vitro analyses were carried out to determine the efficacy of the lyophilized products. In the in vivo test, the delayed type hypersensitiv...

BACKGROUND We analyse whether the tuberculin skin test is a good survival marker in a cohort of pulmonary tuberculosis patients with HIV infection (PTB/HIV). In all, 494 PTB/HIV patients were enrolled in Barcelona (Spain) between January 1992 and December 1994 in the Tuberculosis Program of Barcelona. The main data problem was the large proportion of missing values in the covariates percentage ...

AIMS Tissue fibrosis is a common and serious consequence of chronic inflammation. The mechanism linking these two processes is poorly understood. The present study has utilised a human in vivo model of a delayed type hypersensitivity (DTH) reaction, the tuberculin Heaf reaction, induced by intradermal tuberculin in BCG immunised subjects, to dissect the relation between these two processes. M...