نتایج جستجو برای: trpv3
تعداد نتایج: 245 فیلتر نتایج به سال:
The TRPV3 channel, the dominant TRP receptor in skin, is heavily involved skin physiology. non-selective cation channel highly expressed keratinocytes and regulates epidermal barrier formation, hair follicle growth keratinocyte-mediated inflammation while also mediating cutaneous itch pain sensation. Gain of function mutations have been identified severe diseases, such as Olmsted syndrome, demo...
Thermosensation is mediated by ion channels that are highly temperature-sensitive. Several members of the family of transient receptor potential (TRP) ion channels are activated by cold or hot temperatures and have been shown to function as temperature sensors in vivo. The molecular mechanism of temperature-sensitivity of these ion channels is not understood. A number of domains or even single ...
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Olmsted syndrome (OS) is a rare keratinization disorder, typically characterized by two primary diagnostic hallmarks--mutilating palmoplanter and periorificial keratoderma. However, there's a growing body of literature reporting on the phenotypic diversity of OS, including the absence of aforementioned hallmarks and the presence of some unusual clinical features. Here we presented an atypical f...
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