Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo conversion to a mesenchymal phenotype contributing to wound repair by fibrosis and to cancer cell acquisition of invasive ability. Recently, we showed that type II TGF-β receptor interacting protein-1 (TRIP-1), a protein identified as a phosphorylation target of the TGF-β type II receptor kinase and as a func...

In contrast to white adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and inducible energy expenditure. Obesity is associated with reduction of BAT function; however, it is not well understood how obesity promotes BAT dysfunction, especially at the molecular level. Here we show that the transcription regulator TRIP-Br2 mediates ER stress-induced inhibiti...

TANK-binding kinase 1 (TBK1) plays an essential role in Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I)-mediated induction of type I interferon (IFN; IFN-α/β) and host antiviral responses. How TBK1 activity is negatively regulated remains largely unknown. We report that TNF receptor-associated factor (TRAF)-interacting protein (TRIP) promotes proteasomal degradation of TBK1...

This study aims to explore the trip fuel consumption from a large-scale dataset. To better understand how the multiple variables (e.g., average travel speed, trip distance) influence the trip fuel consumption, we propose the support vector machine (SVM) to learn the relationship between the trip fuel consumption and the corresponding factors. A large-scale GPS and CAN (Controller Area Network) ...

I/S Nordforbrænding is an inter-municipal waste management company located north of Copenhagen, the capital of Denmark, which serves approximately 180,000 inhabitants. It was founded in 1965 and it is owned by six municipalities in North Sealand: Allerød, Søllerød, Hørsholm, Fredensborg-Humlebæk, Karlebo and Helsingør as shown in Fig. 1. The company’s mission was to establish a Waste-to-Energy ...

One of the most important aims of each treatment planning system is the ability of delivering a target conformal dose distribution. Developed and successful used within the heavy ion therapy pilot project, the TReatment plannIng for Particles ( TRiP )[1] is characterised by the capability of delivering exact results in relatively short time, making it possible to rapidly verify and, if necessar...

BACKGROUND One of the most important complications for women during hajj trip is menstruation and most commonly spotting, which is the second important problem. This complication would cause some problems in performing religious rites as the main purpose of the trip and on the other hand, it would lead to psychologic complications for women. Controlling psychologic complications of women during...

On 28 December 2014, the Beijing subway’s fare policy was changed from “Two Yuan” per trip to the era of Logging Ticket Price, charging users by travel mileage. This paper aims at investigating the effects of Beijing subway’s new fare policy on the riders’ attitude, travel pattern and demand. A survey analysis was conducted to identify the effects of the new fare policy for Beijing subway on ri...

INTRODUCTION Providing HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach-based testing or respondent-driven sampling (RDS) in Odessa, Ukraine. METHODS The Transmission Reduction Intervention Project (TRIP) used ris...

Carsharing as a means to provide individuals with access to automobiles to complete a personal trip has grown significantly in recent years in China. However, there are few case studies based on operational data to show the role carsharing systems play in citizens’ daily trips. In this study, vehicle GPS data of a round-trip carsharing system in Hangzhou, China was used to describe the trip cha...