Transforming growth factor beta receptor II interacting protein 1 (TRIP-1), a predominantly intracellular protein is localized in the ECM of bone. TRIP-1 lacks a signal peptide, therefore, in this study, we provide evidence that intracellular TRIP-1 can be packaged and exported to the ECM via exosomes. Overexpression of TRIP-1 in MC3T3-E1 cells resulted in increased matrix mineralization during...

The main goal of this study was to obtain insight about the factors that influence students' ability to learn during a field trip, in order to improve the planning and execution of learning field trips. The study was conducted in the context of a 1-day geological field trip for high school students in Israel. Three domains were tested by observations and questionnaires: (1) the nature of the le...

The combined distribution and assignment problem is the problem of the simultaneous determination of the distribution of trips between origins and destinations in a transportation network and the assignment of trips to routes in each origin{ destination pair. In the model most widely used the distribution is assumed to follow a gravity model with negative exponential deterrence function and the...

Modern embedded systems present an ever increasing complexity and model-driven engineering has been shown to be helpful in mitigating it. In our previous works we exploited the power of model-driven engineering to develop a round-trip approach for aiding the evaluation and assessment of extra-functional properties preservation from models to code. In addition, we showed how the round-trip appro...

Development of dynamic Web sites is often performed by teams consisting of graphic designers and software developers. Communication between these different team members has to be supported with a simple modeling approach that considers their different academical backgrounds. Dynamic Web sites can contain multiple modules that may reappear on different pages. Reuse of both business logic and vis...

the purpose of the study was to identify and prioritize the educational needs and support needed by agricultural extension agents in isfahan, islamic republic of iran. the target population for the study consisted of s3 agricultural extension agents in isfahan province. census population were used therefore, sampling procedures were not utilized and genera i izability of the results was lim...

The onset and degree of injury occurring in animals that develop hyperoxic acute lung injury (HALI) is dependent on age at exposure, suggesting that developmentally regulated pathways/factors must underlie initiation of the epithelial injury and subsequent repair. Type II TGFβ receptor interacting protein-1 (TRIP-1) is a negative regulator of TGFβ signaling, which we have previously shown is a ...

The process of selection, configuration and consumption of tourist information services is a complex task for the user. This is not least since existing tools most often focus on supporting either the preor post-trip phase or the on-trip phase itself by providing context-aware services. The goal of this thesis is to establish a framework that makes pre-trip services context-aware, thus reducing...

ound-trip translation (RTT), otherwise known as reverse translation or back-and-forth translation, involves the translation of text from one language to another (the forward translation or FT) and back again (the back translation or BT), e.g., a paragraph written in English can be translated to Spanish, and then, the resulting Spanish text can be translated back to English again. RTT has been u...

In this paper we first considered a maximum likelihood estimation of trip distribution problem and next use primal-dual geometric programming method the said trip distribution problem converted into an entropy maximization trip distribution problem. Here the generalized cost function is assumed in different form, and then the said formulation is equivalent to single or multi-objective entropy m...