BACKGROUND Brown adipose tissue research is in the focus in the field of endocrinology. We designed a dual-modal fluorescent/PET fatty acid based tracer on commercially available Bodipy-C16, which can be synthesized to its corresponding triglyceride and which combines the benefits of fluorescent and PET imaging. METHODS Bodipy-C16 was coupled to 1,3-diolein resulting in Bodipy-triglyceride. B...

Using the hypertriglyceridemic recall group of the Princeton School Family Study, we assessed the effectiveness and ramifications of family sampling based on hypertriglyceridemic probands and examined whether within-family correlations of lipids and lipoproteins outlast the period of shared common household environments. Thirty-two pediatric and 35 adult probands (who had fasting plasma triglyc...

Using the hypertriglyceridemic recall group of the Princeton School Family Study, we assessed the effectiveness and ramifications of family sampling based on hypertriglyceridemic probands and examined whether within-family correlations of lipids and lipoproteins outlast the period of shared common household environments. Thirty-two pediatric and 35 adult probands (who had fasting plasma triglyc...

The central question I investigated in my research this semester was how the cholesterol and triglyceride metabolic pathways interact in macrophages when cholesterol levels are high. What factors prevent or enhance macrophage ability to regulate cholesterol metabolism? We have preliminary evidence that excessive cholesterol accumulation in macrophages alters triglyceride metabolism in these cel...

Abstract Background Triglyceride (TG) deposit cardiomyovasculopathy (TGCV) is a novel cardiovascular disorder and was recently encoded as an orphan disease in Europe (ORPHA code: 565612). Defective intracellular lipolysis results TG accumulation the myocardium coronary arteries TGCV. The myocardial washout rate (WR) of iodine-123-β-methyl-p-iodophenylpentadecanoic acid (BMIPP) essential indicat...