OBJECTIVES We aimed to examine the temporal association between selective serotonin reuptake inhibitors (SSRI) and tricyclic antidepressant (TCA) prescriptions and suicide-related events in children and adolescents. DESIGN Self-controlled case series. SETTING Electronic health records were used from 479 general practices in The Health Improvement Network (THIN) UK primary care database from...

BACKGROUND Migraine is a chronic neurological disorder, characterized by recurrent moderate to severe headaches. Worldwide migraine affects nearly 15%. Studies suggest that genes involved in the production of nitric oxide (NO) may act as genetic factors for migraine. NO synthase 3 (NOS3) by expressing enzyme NOS regulates endothelial derived NO. One class of medications used as first-line treat...

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...

OBJECTIVE To determine the cost effectiveness, from the Brazilian Ministry of Health viewpoint, of three antidepressant classes for major depressive disorder (MDD), and the budget impact of introducing serotonin-noradrenaline (norepinephrine) reuptake inhibitors (SNRIs) into the current Brazilian national drug formulary, assuming a 6-month treatment duration. METHODS An existing decision-tree...

Suicide is a serious social problem in many countries, including Japan. The majority of people who commit suicide suffer from depression. Suicide attempt patients suffering from serious physical injuries are initially treated in hospital emergency departments. The present post hoc analysis examined data from patients admitted to an emergency hospital for treatment of physical injuries, resultin...

BACKGROUND Several medications commonly used to treat generalized anxiety disorder (GAD) have been designated "potentially inappropriate" for use in patients aged > or =65 years because their risks may outweigh their potential benefits. The actual extent of use of these agents in clinical practice is unknown, however. METHODS Using a database with information from encounters with general prac...