Onychomycosis is predominantly caused by the dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes and Trichophyton tonsurans. The main treatment obstacle concerns low nail-plate drug permeability. In vitro antifungal photodynamic treatment (PDT) and nail penetration enhancing effectiveness have been proven for multifunctional photosensitizer 5,10,15-tris(4-N-methylpyridinium)-20-(4-(b...

BACKGROUND Tinea capitis affects mainly children. The frequency and causative organism vary from region to region. OBJECTIVES To provide epidemiological and mycological data on tinea capitis collected in urban and rural areas of the Dominican Republic. METHODS Samples were obtained from 118 patients with tinea capitis. Sixty-three of these were from 2 schools in urban areas of the Dominican...

A 7-year-old boy was brought for evaluation of a rash on the chin that had appeared 2 weeks earlier. It was slightly itchy. The mother had applied a topical corticosteroid for a few days but then stopped because of worsening of the lesion. The erythematous, scaly lesion with a well-defined border on this boy's face is characteristic of tinea faciei. As the lesion spreads peripherally, the cente...

Cassia alata Linn is an important medicinal plant as well as ornamental flowering plant. The leaf decoction of Cassia alata has been used to treat infectious diseases in north eastern Nigeria. This study was embarked upon so as to evaluate the safety and efficacy of Cassia alata in the management of fungal infectious diseases. The leaves of the plant were collected, dried and extracted using wa...

OBJECTIVE To isolate and identify fungal pathogens associated with dermatophytoses in diabetic patients and identify the spectrum of yeasts colonising diabetic foot ulcers at Kenyatta National Hospital. DESIGN A cross sectional Laboratory based study. SETTING The Kenyatta National Hospital diabetic clinic. SUBJECTS Sixty one patients with diabetic foot ulcers from August to November 2009....

The development of resistance to current antifungal therapeutics drives the search for effective new agents. The fact that some acetophenone-derived Mannich bases had shown antifungal activities in our previous studies led us to design and synthesize acetophenone-derived bis Mannich bases, B1-B5, bis(beta-aroylethyl)methylamine hydrochlorides, to evaluate their antifungal activity. These bis Ma...

Onychomycosis is a common fungal nail infection in adults that is difficult to treat. The in vitro antifungal activity of efinaconazole, a novel triazole antifungal, was evaluated in recent clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, and Candida albicans, common causative onychomycosis pathogens. In a comprehensive survey of 1,493 isolates, efinaconazole MICs against ...