2-Imidazolines and imidazoles have been accessed by an aza-Wittig sequence featuring novel N-acylation methodology for sulfonamides and optimized conditions for ring closure.

Nickel(0) catalysts were used to produce substituted imidazoles in good to high yields using benzonitrile, p-substituted benzonitriles and 4-cyanopyridine as starting materials.

The interaction of a few azole derivatives, 2-(4'-N,N-dimethylaminophenyl)benzimidazole, 2-(4'-N,N-dimethylaminophenyl)benzoxazole, 2-(4'-N,N-dimethylaminophenyl)oxazolo[4,5-b]pyridine with bovine serum albumin (BSA) were examined by absorption and fluorescence spectroscopy. The results were compared with the previously studied imidazopyridine derivative 2-(4'-N,N-dimethylaminophenyl)imidazo[4,...

The effect of spray drying on the different polyphenolic compounds present in root a purple-fleshed sweet potato variety Ipomoea batatas native from Peru was performed by HPLC-QTOF-MSMS. Nine anthocyanins, including four peonidin, three cyanidin and two pelargonidin derivatives glycosylated with sophorose and/or glucose acylated caffeic, ferulic p-hydroxybenzoic acid were identified. Twenty nin...

Introduction: Acute pulmonary embolism (PE) is one of the deadly cardiovascular diseases. One of the indexes proposed in these patients for risk stratification is the Thrombolysis in Myocardial Infarction (TIMI) risk index (TRI), which includes three parameters of systolic blood pressure, age, and heart rate. This study aimed to evaluate the predictive value of TRI on in-hospit...

In this paper, the energy absorption features of tri-layer explosive-welded deep-drawn cups subjected to quasi-static axial compressive loading are investigated numerically and experimentally. To produce the cups, tri-layer blanks composed of aluminum and stainless steel alloys were fabricated by an explosive-welding process and formed by a deep drawing setup. The quasi-static tests were carrie...

A promising approach for treating diabetes mellitus (DM) is to decrease postprandial hyperglycaemia by suppressing carbohydrate digestion using α-glucosidase inhibitors. Pluchea indica leaf extracts possess inhibitory activity against intestinal maltase. Enzyme assay-guided fractionation by chromatography yielded five active caffeoylquinic acid derivatives (1-5). Their structures were elucidate...

Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their s...

[this article has been retracted for duplicate publication] background: the pathological classification of cryptogenic fibrosing alveolitis has been a matter of debate and controversy for histopathologists. objective: to identify and specify the glycotypes of capillary endothelial cells in usual interstitial pneumonia (uip) compared to those found in normal tissue. methods: sections of formalin...