Our study assessed the impact of a computer alert that reminded clinicians to test men who were at higher risk for syphilis on the rate of syphilis testing and diagnoses. The percentage of high-risk men who have sex with men who were tested for syphilis increased from 77% to 89% (P>.001), and the percentage of such men with asymptomatic syphilis increased from 16% to 53% (P=.001).

Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study. Maternal syphilis, diagnosed serologically using Venereal Disease Research Laboratory titer plus Treponema Pallidum Hemagglu...

TP0658 (FliW) and its orthologs, conserved proteins of unknown function in Treponema pallidum and other species, interact with a C-terminal region of flagellin (FlaB1-3 in T. pallidum; FliC in most other species). Mutants of orthologs in Bacillus subtilis and Campylobacter jejuni (yviF, CJ1075) showed strongly reduced motility. TP0658 stabilizes flagellin in a way similar to FliS, suggesting th...

transcriptional activator NF-kappa B. lipopolysaccharide but involves the proceeds via a pathway distinct from that of lipoproteins and synthetic lipopeptides Treponema pallidum and Borrelia burgdorferi Activation of human monocytic cells by

Syphilis is a sexually transmitted disease caused by Treponema pallidum and divided into three stages according to the duration of the disease: primary, secondary and tertiary. Secondary syphilis has diverse clinical presentations, such as papular-nodular lesions. This presentation is rare, with 15 cases reported in the literature over the past 20 years. We report a case of secondary syphilis w...

The bactericidal activity of the aminoglycoside gentamicin has been demonstrated against a broad spectrum of bacteria (Jackson and Finland, 1969). This spectrum included Neisseria gonorrhoeae (Waitz and Weinstein, 1969); however, before gentamicin is used for the treatment of gonorrhoea, its effect on Treponema pallidum should be investigated to determine whether it can delay or mask the develo...

Optimum parameters for retention of motility of Treponema pallidum (Nichols virulent strain) were found by anaerobic co-incubation of the treponeme with rat glial cells and anaerobic incubation in spent medium obtained from glial cells originally grown aerobically.

BACKGROUND Syphilis is resurgent in many regions of the world. Molecular typing is a robust tool for investigating strain diversity and epidemiology. This study aimed to review original research on molecular typing of Treponema pallidum (T. pallidum) with three objectives: (1) to determine specimen types most suitable for molecular typing; (2) to determine T. pallidum subtype distribution acros...

It has long been known that Treponema pallidum, subspecies pallidum can in late stages of neurosyphilis cause dementia, cortical atrophy, and amyloid deposition. The occurrence of dementia, including subacute presenile dementia, was also reported in association with Lyme disease caused by another spirochete, Borrelia burgdorferi. Both spirochetes are neurotropic and in both diseases the neurolo...