Dropout rates from detoxification treatment are high. We tested whether high trauma event load was related to a higher dropout from alcohol detoxification. Furthermore, we studied the feasibility and effects of a short psychoeducational tool to increase retention among traumatized alcohol in-patients. Retention and treatment length were compared between treatment as usual (TAU) and standard the...

BACKGROUND Depressive symptoms and reduced quality of life (QOL) are parts of the chronic stress syndrome and predictive of adverse outcome in patients with ischemic heart disease (IHD). Chronic stress is associated with increased sensitivity for pain, which can be measured by algometry as Pressure Pain Sensitivity (PPS) on the sternum. AIM To evaluate if stress focus by self-measurement of P...

Background: Theoretically, mindfulness or the non-judgmental awareness of present generates eudaimonic well-being. Mindfulness-based interventions are effective for addictions like alcohol-dependence but its well-being outcomes should be validated empirically. Objectives: Current pilot study intended to explore feasibility a novel intervention, Mindfulness-Based Eudaimonic Enhancement Training ...

Meru Health Program (MHP) is a therapist-guided, 8-week intervention for depression delivered via smartphone. The aim was to test its efficacy in patients with clinical Finnish university student health service. Patients (n=124, women 72.6%, mean age 25y) were stratified based on antidepressant status, and randomized into group receiving MHP plus treatment as usual (TAU), control TAU only. Depr...

Background: Substance use disorders (SUD) are patterns of substance use leading to severe impairment on social, working and economic levels. In vivo and clinical findings have enhanced the role of the brain's stress-related system in maintaining SUD behaviors. Several studies have also revealed a high prevalence of post-traumatic symptoms among SUD patients, suggesting that a trauma-informed tr...

DNA of 258 patients with treatment-resistant depression was collected in three 8-10 week, two-arm, prospective clinical trials. Forty-four allelic variations were measured in genes for the cytochrome P450 (CYP) enzymes CYP2D6, CYPC19, and CYP1A2, the serotonin transporter (SLC6A4), and the 5-HT2A receptor (HTR2A). The combinatorial pharmacogenomic (CPGx™) GeneSight test results were provided to...

Abstract Background The general aim of this study was to investigate the effectiveness blended Cognitive Behavioral Therapy (bCBT) as compared Treatment Usual (TAU) for depression in specialized routine mental healthcare Netherlands. We further explored a range secondary outcome variables, including quality life, clinical response, remission and reliable improvement, well deterioration potentia...

BACKGROUND Major depressive disorder (MDD) is projected to rank second on a list of 15 major diseases in terms of burden in 2030. The major contribution of MDD to disability and health care costs is largely due to its highly recurrent nature. Accordingly, efforts to reduce the disabling effects of this chronic condition should shift to preventing recurrence, especially in patients at high risk ...