Persistent patency of the ductus arteriosus in the preterm infant is associated with numerous morbidities, including higher rates of bronchopulmonary dysplasia and increased mortality. These strong associations have led to widespread use of cyclooxygenase inhibitors and surgical ligation to achieve ductal closure in the expectation that closing the ductus will reduce these complications. Each o...

Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The principal risk factors forPTSarepersistent legsymptoms1month after the acute ep...

POEMS syndrome is a paraneoplastic syndrome whose acronym stands for less than half of the defining features of the disease, that is, polyradiculoneuropathy, organomegaly, potentially including coexisting Castleman disease, endocrinopathy, monoclonal plasma cell neoplasm, and skin changes. The other important features include papilledema, extravascular volume overload, sclerotic bone lesions, t...

Large granular lymphocyte (LGL) leukemia is characterized by a clonal expansion of either CD3 cytotoxic T or CD3 NK cells. Prominent clinical features of T-LGL leukemia include neutropenia, anemia and rheumatoid arthritis (RA). The terminal effector memory phenotype (CD3 /CD45RA /CD62L CD57 ) of T-LGL suggests a pivotal chronic antigen-driven immune response. LGL survival is then promoted by pl...

Despite advances in treatment, there was little evidence until recently that this led to improvement in the survival of patients with indolent lymphoma, with patients continuing to have an unremitting course of relapse of disease. There appears to have been a change in the natural history of these diseases with the introduction of chemoimmunotherapy that may finally result in improvements in su...

b Strep. agalactiae is easily cured by approved antibiotic infusion products. b Therapy of Staph. aureus mastitis greatly improves with extended or combination therapy. b Extra-label treatment requires a valid veterinary/patient/client relationship. b Oxytocin is effective in alleviating clinical symptoms of coliform mastitis. b Antibiotics are more effective against Gram-positive than Gram-neg...

Primary postpartum hemorrhage (PPH), defined by the Royal College of Obstetricians and Gynaecologists as bleeding of .500 mL in the first 24 hours of childbirth, complicates 13% of deliveries. Improved awareness, better obstetric care, and involvement of multidisciplinary teams has reduced the incidence of PPH overall, but temporal trends have shown an increase inmajor obstetric hemorrhage. In ...

To discuss diagnostic strategies and management options in cases with suspected valsalva maculopathy (VM), to optimize visual outcome. We describe six cases with suspected VM. The preretinal hemorrhage resolved spontaneously in four out of six patients, without any intervention. One patient underwent neodymium-doped yttrium aluminum garnet hyaloidotomy and the other proceeded to have a vitrecto...

The Oncologist 2005;10:332–334 www.TheOncologist.com Correspondence: Patrick G. Johnston, M.D., Ph.D., FRCP, FRCPI, Department of Oncology, Queen’s University Belfast, University Floor, Belfast City Hospital, Belfast BT9 7AB, Northern Ireland. Telephone: 44-28-90-263911; Fax: 44-28-90263744; e-mail: [email protected] Received March 8, 2005; accepted for publication March 18, 2005. ©AlphaMed Pr...