The requisite role of HER3 in HER2-amplified cancers is beyond what would be expected as a dimerization partner or effector substrate and it exhibits a substantial degree of resiliency that mitigates the effects of HER2-inhibitor therapies. To better understand the roots of this resiliency, we conducted an in-depth chemical-genetic interrogation of the signaling network downstream of HER3. A un...

Plug-in Electric Vehicle (PEV) charging stations couple future transportation systems and power systems. That is, PEV driving and charging behavior will influence the two networks simultaneously. This paper studies optimal planning of PEV fast-charging stations considering the interactions between the transportation and electrical networks. The geographical targeted planning area is a highway t...

With the growing demand for air transportation and the limited ability to increase capacity at key points in the air transportation system, there are concerns that, in the future, the system will not scale to meet demand. This situation will result in the generation and the propagation of delays throughout the system, impacting passengers’ quality of travel and more broadly the economy. There i...

The objective of the paper is to discuss the development of an alternative representation of the transportation network using object-oriented GIS. This representation is important for the supply side of transportation planning and modeling. Object-orientation provides a way of solving the problem in a planar network for routing. It can facilitate the calculation of detailed network characterist...

In this paper, a comprehensive model for hub location-routing problem is proposed which no network structure other than connectivity is imposed on backbone (i.e. network between hub nodes) and tributary networks (i.e. networks which connect non-hub nodes to hub nodes). This model is applied in public transportation, telecommunication and banking networks. In this model locating and routing is c...

social capital is one of the most important criteria related to social network resilience. in trust networks as the most important factor of social capital in adaptive governance, sensitivity to disorders and irregularities is considerable and resiliency improvement and compatibility capacity depends on trust level in network. this research is applied in zangooi village, south khorasan province...

In this paper, we present a mathematical programming model based on a timespace network representation for solving real-time transportation problems in forestry. We cover a wide range of unforeseen events that may disrupt the planned transportation operations (e.g., delays, changes in the demand and changes in the topology of the transportation network). Although each of these events has differ...

We investigate the resiliency of the Internet at the Autonomous System (AS) level to failures and attacks, under the real constraint of business agreements between the ASs. The agreements impose policies that govern routing in the AS level, and thus the resulting topology graph is directed, and does not maintain transitivity. We show, using partial views obtained from the Internet, that the Int...