The Sibling Donor Cord Blood (SDCB) Program was initiated in 1998 as a resource to collect, characterize, and release cord blood units (CBUs) from families affected by malignant and nonmalignant disorders for transplantation. Families in the United States were recruited by telephone after referrals by community and academic physicians. Collection kits were mailed to prospective participants and...

In 2003 there were 8,665 transplants of deceased donor kidneys for the approximately 60,000 patients waiting for such transplants in the United States. While waiting, 3,436 patients died. There were also 6,464 kidney transplants from living donors (Scientific Registry of Transplant Recipients web site). Live donation is an option for kidneys, since healthy people have two and can remain healthy...

BACKGROUND Transplantation of mononuclear cells (MNCs) has previously been tested as a method to induce therapeutic angiogenesis to treat limb ischemia in clinical trials. Non-invasive high resolution imaging is required to track the cells and evaluate clinical relevance after cell transplantation. The hypothesis that MRI can provide in vivo detection and long-term observation of MNCs labeled w...

one of the main problems following road accidents is brain injury after which death and disability in the most active population occurs. considering the fact that there is no definite clinical treatment for repair of damaged brain tissue, the present study examined the effects of autologous adult neural stem/progenitor cells (ns/pcs) seeded in a nanoscaffold named puramatrix in acute brain inju...

Passive transfer of transplantation immunity was accomplished in inbred guinea pigs with tritiated thymidine-labeled lymphoid cells sensitized to homologous tissues. Autoradiographs of the homologous skin graft sites disclosed the presence of relatively few or no labeled cells at the site of rejection. Passive transfer of transplantation immunity was also accomplished with sensitized lymphoid c...

Olfactory ensheathing cells (OECs) prepared from the olfactory bulbs of adult transgenic Sprague Dawley (SD) rats expressing green fluorescent protein (GFP) were transplanted into a dorsal spinal cord transection lesion of SD rats. Five weeks after transplantation, the cells survived within the lesion zone and oriented longitudinally along axons that bridged the transection site. Although the h...

Corneal transplantation is among the most prevalent and successful forms of solid tissue transplantation in humans. Failure of corneal allograft is mainly due to immune-mediated destruction of the graft, a complex and highly coordinated process that involves elaborate interactions between cells of innate and adaptive immunity. The migration of immune cells to regional lymphoid tissues and to th...

TISSUE LOSS OR END-STAGE ORGAN FAILURE caused by injury or other types of damage is one of the most devastating and costly problems in human health care. Surgical strategies that have been developed to deal with these problems include organ transplantation from one individual to another, tissue transfer from a healthy site to the diseased site in the same individual, and replacement by using me...