OBJECTIVE Cystic fibrosis (CF)-related diabetes has been regarded as a mild form of diabetes with a low risk of severe diabetes complications. The prevalence of CF-related diabetes increases with age, resulting in a 50% prevalence of diabetes at age 30 years. We sought to investigate whether microvascular complications in CF-related diabetes appear with a relevant frequency. RESEARCH DESIGN A...

Renal transplant is now the accepted mode of treatment of end stage renal disease (ESRD). The major causes of ESRD being diabetes mellitus, hypertension, glomerulonephritis, polycystic kidney disease and other/unknown. The most common glomerular disease in renal allograft biopsies is transplant glomerulopathy, i.e., those lesions related to transplant rejections. Other glomerulonephropathies (G...

We contacted and analyzed the data of 18 lung transplant recipients who had had children. The complications we detected included: hypertension (50%), diabetes mellitus (21%), preeclampsia (13%), infection (21%), rejection (30%), loss of graft function (23%) and a lower percentage of live births than in transplant recipients of other organs. Other aspects to keep in mind are: the potential risk ...

A 56-year-old female patient was referred to the transplant assessment clinic in July 2016. She started haemodialysis in 2012 for renal failure due to urinary tract infections. She is doing very well on dialysis and has an excellent exercise tolerance without shortness of breath or angina. She has had no infections since starting dialysis and no other comorbidity, except well-controlled hyperte...

Worldwide, more than 250,000 individuals who have received a liver, heart, lung, or intestinal transplant are living longer. Twenty percent to 25% of these recipients experience perioperative acute renal failure, with 10% to 15% requiring renal replacement therapy. Chronic kidney disease (CKD) is also highly prevalent, affecting 30% to 50% of the nonrenal organ transplant population with an ann...

OBJECTIVE The purpose of the present study was to validate various surrogate estimates of insulin sensitivity (IS) in a renal transplant population and to assess the influence of immunosuppressive and antihypertensive therapy on insulin resistance (IR) after renal transplantation. RESEARCH DESIGN AND METHODS A total of 167 consecutive renal transplant recipients without previously known diabe...

Callus R, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220307 Description A 50-year-old man with known hypertension, diabetes controlled on diet and end-stage kidney disease of unknown aetiology received a donor after brain death renal allograft from an extended criteria donor. There was initial delayed graft function, followed by a reduction in serum creatinine to a nadir of 115 μmol/L. Main...

Area-Under-the-Concentration Curve, Bruce Kaplan,* Herwig-Ulf Meier-Kriesche, Kimberly Napoli, and Barry D. Kahan (Div. of Renal Dis. and Hypertension, Dept. of Internal Med., and Div. of Immunol. and Organ Transplant., Dept. of Surgery, The University of Texas Medical School at Houston, 6431 Fannin, Suite 4.163, Houston, TX 77030; *author for correspondence and reprint requests: fax 713-794-1197)

OBJECTIVES Pneumonia is an important cause of morbidity and mortality in recipients of solid-organ transplant. We aimed to determine risk factors for development of pneumonia and associated deaths in kidney transplant recipients. MATERIALS AND METHODS A retrospective review of medical records was performed for all kidney transplant recipients from December 1988, to April 2011. The diagnosis o...

Survival after heart transplantation has improved considerably over the past 20 years. Half of all patients now live 9 years, and 25% live 17 years.1 Currently, 20 000 heart transplant recipients live in the United States.2 Improved longevity means prolonged immunosuppression and the concomitant use of drugs to prevent or treat the long-term complications of immunosuppressive agents, such as in...