In October 2006, the National Institutes of Health launched a new national consortium, funded through Clinical and Translational Science Awards (CTSA), with the primary objective of improving the conduct and efficiency of the inherently multi-disciplinary field of translational research. To help meet this goal, the Ohio State University Center for Clinical and Translational Science has launched...

This multi-author book has been published in consonance with the growing interest in translational medicine (TM). It consists of 11 chapters. The first chapter introduces and explains the concept of TM. It takes us through the history of TM and analyses the obstacles, low output syndrome in terms of true medical innovations as well as its implications on big pharmaceutical companies. In short, ...

BACKGROUND Maximizing efficiency in drug development is important for drug developers, policymakers, and human subjects. Limited funds and the ethical imperative of risk minimization demand that researchers maximize the knowledge gained per patient-subject enrolled. Yet, despite a common perception that the current system of drug development is beset by inefficiencies, there remain few approach...

Nick Lemoine is at the Institute of Cancer, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK. It is evident that clinician-scientists are high-fliers, but also increasingly obvious that they are rare and endangered Translation requires individuals who are fluent in two languages, and this is equally true of translational medicine, for which clinicia...

Nicotine addiction accounts for 4.9 million deaths each year. Furthermore, although smoking represents a significant health burden in the United States, at present there are only three FDA-approved pharmacotherapies currently on the market: (1) nicotine replacement therapy, (2) bupropion, and (3) varenicline. Despite this obvious gap in the market, the complexity of nicotine addiction in additi...

Objective. To assess reliability, validity, and responsiveness of a 29-item short-form version of the Patient Reported Outcomes Measurement Information System (PROMIS) and a novel “impact score” calculated from those measures. Design. Prospective cohort study. Setting. Rural primary care practices. Subjects. Adults aged 55 years with chronic musculoskeletal pain, not currently receiving prescri...